来氟米特联合环磷酰胺对狼疮性肾炎患者血清白蛋白及补体C3水平的影响

Effect of Leflunomide combined with Cyclophosphamide on serum albumin and complement C3 levels in patients with lupus nephritis

目的探讨狼疮性肾炎(LN)患者应用来氟米特联合环磷酰胺治疗的临床效果。方法选择2019年4月至2021年4月九江市第一人民医院收治的84例LN患者作为研究对象,采用随机数字表法将其分为观察组(42例)及对照组(42例)。两组均予以泼尼松治疗,观察组同时给予环磷酰胺加用来氟米特治疗,对照组同时给予环磷酰胺治疗。两组均持续用药6个月。比较两组的临床疗效、肾功能指标、血清白蛋白和补体C3水平,并记录不良反应发生情况。结果观察组的治疗总有效率高于对照组,差异有统计学意义(P<0.05);观察组治疗后的血尿素氮(BUN)、血肌酐(SCr)、24 h尿蛋白量水平均低于对照组,血清白蛋白、补体C3水平均高于对照组,差异有统计学意义(P<0.05);两组的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论来氟米特联合环磷酰胺治疗LN效果显著,可有效提高血清白蛋白和补体C3水平,促进肾功能恢复,减轻肾功能损害,缓解临床症状,稳定病情,值得推广应用。

Objective To investigate the clinical effect of Leflunomide combined with Cyclophosphamide in patients with lupus nephritis(LN).Methods A total of 84 LN patients admitted to Jiu Jiang NO.1 People's Hospital from April 2019 to April 2021 were selected as the study objects and they were divided into observation group(42 cases)and control group(42 cases)by random number table method.Both groups were treated with Prednisone,the observation group was also treated with Cyclophosphamide and Flunomide,and the control group was also treated with Cyclophosphamide.Both groups were treated continuously for 6 months.The clinical efficacy,renal function indexes,serum albumin and complement C3 levels were compared between the two groups,and adverse reactions were recorded.Results The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of blood urea nitrogen(BUN),serum creatinine(SCr)and 24 h urinary protein in observation group were lower than those in control group,and the levels of serum albumin and complement C3 were higher than those in control group,with statistically significant differences(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Leflunomide combined with Cyclophosphamide is effective in the treatment of LN,which can effectively improve the levels of serum albumin and complement C3,promote the recovery of renal function,reduce renal damage,alleviate clinical symptoms and stabilize the disease,and is worthy of promotion and application.