小而密低密度脂蛋白和同型半胱氨酸在脑梗死风险评估的价值及颈动脉粥样硬化病变程度的相关性研究

Value of small and dense low-density lipoprotein and homocysteine in the risk assessment of cerebral infarction and the correlation between the degree of carotid atherosclerosis

目的研究小而密低密度脂蛋白(dsLDL)和同型半胱氨酸(Hcy)在脑梗死风险评估中的应用价值。方法选取2022年8月至2023年7月于阳江市中医医院完成颈动脉彩色多普勒超声检查91例脑梗死患者,选择同期健康体检者91人为研究对象,比较两组人群的sdLDL和血清Hcy水平,分析sdLDL和Hcy水平的诊断效能;分析脑梗死患者sdLDL和Hcy血清水平与颈动脉硬化程度的相关性。结果脑梗死患者血清中sdLDL和Hcy水平高于健康人群,差异有统计学意义(P<0.05),sdLDL和Hcy联合检测对脑梗死患者有较好的诊断效能,AUC为0.98,敏感度为96.5%,特异度为90.5%;脑梗死患者中颈动脉病变程度与sdLDL和Hcy的水平呈正相关(P<0.05)。结论sdLDL和Hcy在脑梗死风险评估中具有重要的应用价值,可评估脑梗死患者的颈动脉硬化程度。

Objective To investigate the application value of small and dense low-density lipoprotein(dsLDL)and homocysteine(Hcy)in the risk assessment of cerebral infarction.Methods Ninety-one patients with cerebral infarction who underwent carotid artery color Doppler ultrasound examination in the Yangjiang Traditional Chinese Medicine Hospital from August 2022 to July 2023 were selected as the study objects,and 91 healthy subjects were selected during the same period.Serum levels of sdLDL and Hcy were compared between the two groups to analyze the diagnostic efficacy of serum levels of sdLDL and Hcy.To analyze the correlation between the serum levels of sdLDL and Hcy and the degree of carotid atherosclerosis in patients with cerebral infarction.Results The serum levels of sdLDL和Hcy in patients with cerebral infarction were higher than those in healthy people,and the differences were statistically significant(P<0.05).The combined detection of sdLDL and Hcy has a good diagnostic efficacy in patients with cerebral infarction,with an AUC of 0.98,a sensitivity of 96.5%,and a specificity of 90.5%.There were positive correlations between the degree of carotid artery lesion and the levels of sdLDL and Hcy in cerebral infarction patients(P<0.05).Conclusion SdLDL and Hcy have important application value in the risk assessment of cerebral infarction,can assess the degree of carotid atherosclerosis in patients with cerebral infarction.