D-二聚体对精神科住院患者的临床意义

Clinical significance of D-dimer in psychiatric inpatients

目的探讨D-二聚体(D-dimer)的变化对精神科住院患者的影响及意义。方法选取150例精神科住院患者作为实验组,患者采用抗凝、抗血栓治疗;选取150例同期健康体检者作为对照组。对实验组治疗前后及对照组血浆中的D-二聚体、纤维蛋白原水平进行检测。比较两组D-二聚体、纤维蛋白原水平。结果实验组患者治疗前纤维蛋白原(4.65±0.76)g/L、D-二聚体(0.97±0.29)mg/L均高于对照组的(2.17±0.52)g/L、(0.24±0.06)mg/L,实验组患者治疗后的纤维蛋白原(3.78±0.57)g/L、D-二聚体(0.62±0.21)mg/L均低于治疗前,但仍高于对照组,有显著统计学差异(P<0.05)。结论精神科住院患者体内的D-二聚体含量显著高于正常人,因此对于住院精神患者要加强血栓防治。

Objective To explore the effect and significance of D-dimer in psychiatric inpatients.Methods 150 psychiatric inpatients were selected as the experimental group,and treated with anticoagulation and antithrombotic therapy,and 150 healthy subjects during the same period were selected as the control group.The plasma levels of D-dimer and fibrinogen in the experimental group before and after treatmen and in the control group were measured.The levels of fibrinogen and D-dimer of the two groups were compared.Results Before treatment,the experimental group had fibrinogen of(4.65±0.76)g/L and D-dimer of(0.97±0.29)mg/L,which were higher than(2.17±0.52)g/L and(0.24±0.06)mg/L in the control group;after treatment,the fibrinogen of(3.78±0.57)g/L and D-dimer of(0.62±0.21)mg/L in the experimental group were lower than those before treatment,but still higher than the control group,with statistically significant differences(P<0.05).Conclusion The content of D-dimer in psychiatric inpatients is significantly higher than that in normal people.Therefore,it is necessary to strengthen the prevention and treatment of thrombosis in psychiatric inpatients.