自然杀伤细胞在流感中的作用机制研究进展

Research progress in mechanism of natural killer cells in influenza

流行性感冒病毒(简称流感病毒)每年引起较高的人群发病率和死亡率,对全球公共卫生安全构成严重威胁。流感病毒经过不断进化,具有躲避宿主免疫反应和逃避疫苗保护的能力。因此,有必要开发针对宿主细胞机制的药物或疫苗以降低重症率和死亡率。自然杀伤细胞(NK细胞)能够在非致敏状态下迅速杀伤病毒感染的宿主细胞,并具有免疫调节及记忆效应,为流感病毒的防治带来了希望。该文就NK细胞及其免疫激活在流感中的作用机制进行综述,为流感防治的新型药物或疫苗研究提供依据。

Influenza virus causes high morbidity and mortality every year,which is posing a serious threat to global public health security.Influenza viruses possess the ability to evade host immune responses and evade the vaccine protection.Therefore,it is imperative to develop drugs or vaccines targeting mechanisms of host cell to reduce the incidence rate of severe illness and mortality.Natural killer cells(NK cells)can quickly kill the influenza virus infected cells in a non allergenic state,also have immune regulation and memory effects,which brings hope for the prevention and treatment of influenza viruses.This article reviews the mechanism of NK cells and their immune activation in influenza,in order to provide reference for the researches of new drugs or vaccines for preventing and treating influenza.