基于数据挖掘探讨中药熏洗坐浴治疗肛门病术后肛门水肿的用药规律

A literature study on the treatment of postoperative anal edema with traditional Chinese medicine fumigation and sitz bath based on data mining

目的基于数据挖掘分析中药熏洗坐浴治疗肛门病术后肛门水肿的用药规律。方法分别检索中国知网、万方、维普数据库自建库以来至2022年5月有关中药熏洗、坐浴治疗肛门病术后肛门水肿的文献,将中药处方输入录入Microsoft Excel数据库,进一步筛选后进行药物频数和用药频率统计,以及关联规则、系统聚类、和药物因子分析。结果共纳入处方252首,涉及药物152味,筛选出高频药物35味;用药频次较高的为苦参、黄柏、芒硝;药物功效以清热燥湿、活血化瘀为主;药性以寒、温、微寒为主;药味以苦、辛、甘为主;归经则以肝、心、胃经为主;归纳出关联规则分析出药物组合22条;系统聚类分析得出核心聚类群5个。结论肛门病术后水肿的中医治疗以清热利湿、活血化瘀为基本治则,随证佐以补虚、止血药。

Objective To analyze the regularity of sitz bath with traditional Chinese medicine in the treatment of postoperative anal edema on the basis of data mining.Methods By retrieving literature concerning herbal fumigation and sitz bath to treat postoperative anal edema in CNKI,WangFang Data,and CQVIP from the time when the database was established to May 2022,this research record⁃ed the prescriptions of traditional Chinese medicine into Microsoft Excel.Based on further screening,statistics were carried out on drug frequency and frequency of drug use,and analysis was made of association rules,hierarchical clusters,and drug factors.Results A to⁃tal of 252 prescriptions of traditional Chinese medicine were included,involving 152 Chinese medicines and 35 high-frequency medi⁃cines.Among them,the most frequently used ones were Radix Sophorae Flavescentis,Cortex Phellodendri,and Natrii Sulfas.The main efficacies of the medicines could be summarized as clearing heat,drying dampness,and promoting blood circulation to remove blood stasis.Regarding the medicine properties,cold-property and warm-property as well as cool-property medicines were dominant in all pre⁃scriptions.Additionally,the medicine flavor mainly included bitter,pungent,and sweet flavors.In terms of meridian affinity,liver and heart as well as stomach meridians were dominant in all prescriptions.A total of 22 Chinese medicinal combinations were analyzed through the summarized association rules,while 5 core cluster groups were obtained based on hierarchical cluster analysis.Conclu⁃sion Simply put,the traditional Chinese medicine treatment of postoperative anal edema is based on clearing heat,drying dampness,and promoting blood circulation to remove blood stasis,which is supplemented by tonic and haemostatic medicines according to rele⁃vant symptoms.