生产性粉尘暴露与类风湿关节炎发生风险的研究进展

Research advance on the association between occupational dust exposure and the risk of rheumatoid arthritis

类风湿关节炎(rheumatoid arthritis,RA)是一种与慢性炎症过程相关的自身免疫性疾病,主要影响关节,导致关节疼痛、僵硬和功能障碍等症状。同时,RA是一种慢性致残性疾病,影响患者的生活质量和预期寿命,已成为一个重要的公共卫生问题,给个人和社会带来了负担。其病因和发病机制尚未完全明确,近年来发现生产性粉尘暴露可能是RA发生的危险因素,同时相关的流行病学研究也取得了一定的成就,有利于RA的病因研究、诊断和预防。本研究将综述现有关于生产性粉尘暴露与RA发生的流行病学研究进展,以期提供更深入的研究思路和方向。

Rheumatoid arthritis(RA)is an autoimmune disease associated with chronic inflammation.It primarily affects the joints,leading to joint pain,stiffness,and functional impairment.RA is also a chronic disabling disease that impacts patients′quality of life and life expectancy,making it a significant public health concern that burdens both individuals and society.The etiology and pathogenesis of RA are not fully understood;however,in recent years,studies have suggested that occupational dust exposure may be a risk factor for RA development.Concurrently,epidemiological research has made progress in understanding RA′s causes,diagnosis,and prevention.This article reviews the progress in epidemiological research on the relationship between occupational dust exposure and the occurrence of RA,aiming to provide deeper insights and directions for further investigation.