子宫内膜癌患者血清sVEGFR1、YKL-40、IGF-1表达水平及临床意义研究

The expression levels of serum sVEGFR1,YKL-40 and IGF-1 in patients with endometrial cancer and their clinical significance

目的探究子宫内膜癌患者血清可溶性血管内皮生长因子受体1(sVEGFR1)、甲壳质酶蛋白40(YKL-40)、胰岛素样生长因子1(IGF-1)表达水平及临床意义。方法择取本院100例子宫内膜癌患者作为观察组;另选取同期100例健康体检者作为对照组。比较两组sVEGFR1、YKL-40、IGF-1表达水平并分析观察组不同分期表达水平。结果观察组sVEGFR1表达水平较对照组低,YKL-40、IGF-1表达水平较对照组高,差异有统计学意义(P<0.05)。观察组Ⅰ~Ⅳ期sVEGFR1表达水平明显降低,YKL-40、IGF-1表达水平升高,差异有统计学意义(P<0.05)。结论在子宫内膜癌患者中,sVEGFR1、YKL-40、IGF-1均出现异常表达,不同分期患者存在较大差异,可为疾病诊断与分期提供可靠的数据参考。

Objective To investigate the expression levels and clinical significance of serum soluble vascular endothelial growth factor receptor 1(sVEGFR1),chitinase protein 40(YKL-40)and insulin-like growth factor 1(IGF-1)in patients with endometrial cancer.Methods 100 patients with endometrial carcinoma in our hospital were selected as the observation group.Another 100 healthy subjects were selected as control group.The expression levels of sVEGFR1,YKL-40 and IGF-1 in the two groups were compared,and the expression levels of different stages in the observation group were analyzed.Results The expression level of sVEGFR1 in the observation group was lower than that in the control group,and the expression levels of YKL-40 and IGF-1 were higher than that in the control group,with statistical significance(P<0.05).The expression level of sVEGFR1 in stage Ⅰ to Ⅳ of the observation group was significantly decreased,while the expression levels of YKL-40 and IGF-1 were increased,with statistical significance(P<0.05).Conclusion Abnormal expression of sVEGFR1,YKL-40 and IGF-1 was found in patients with endometrial carcinoma,and there were great differences among patients with different stages,which could provide reliable data reference for diagnosis and staging of the disease.