水蛭治疗脑小血管病所致认知功能障碍的疗效分析

Therapeutic Effect of Leech on Cognitive Impairment Caused by Cerebral Small Vascular Disease

目的探究水蛭饮片治疗脑小血管病(Cerebral Small Vessel Disease,CSVD)所致认知障碍患者的临床疗效。方法方便选取2020年10月—2023年6月广西壮族自治区民族医院神经内科收治的120例CSVD所致认知障碍患者为研究对象,以随机数表法分为对照组和观察组,各60例。对照组实施内科常规西药基础治疗,观察组在对照组治疗基础上增加中药水蛭口服治疗。观察并对比两组的治疗结果。结果治疗后与对照组相比,观察组最小量认知评估量表(Mini Mental State Examination,MMSE)评分、蒙特利尔认知评估量表(Montreal Cognitive Assessment,MoCA)评分更高,差异有统计学意义(P均<0.05)。观察组临床治疗有效率(86.67%)显著高于对照组(71.67%),差异有统计学意义(χ^(2)=4.093,P<0.05)。治疗后与对照组相比,观察组的白细胞介素-6(Interleukin-6,IL-6)和超敏-C反应蛋白(High Sensitive C-reactive Protein,hs-CRP)水平更低,差异有统计学意义(P均<0.05)。结论水蛭能有效减轻CSVD所致认知障碍患者的临床症状,改善患者的认知功能障碍。

Objective To explore the clinical effect of leech decoction tablets in the treatment of cerebral small vessel disease(CSVD)patients with cognitive impairment.Methods 120 patients with cognitive impairment caused by CSVD admitted to the Neurology Department of Guangxi Zhuang Autonomous Region Ethnic Hospital from October 2020 to June 2023 were conveniently selected as the study objects and divided into control group and observation group by random number table method,with 60 cases in each group.The control group received conventional Western medicine basic treatment in the internal medicine department,while the observation group was given oral treatment of Chinese medicine leech on the basis of the control group.The treatment outcomes of the two groups were observed and com-pared.Results After treatment,compared with the control group,the observation group had higher scores on the Mini Mental State Examination(MMSE)and Montreal Cognitive Assessment(MoCA),and the differences were statistically significant(both P<0.05).The clinical treatment effective rate of the observation group(86.67%)was significantly higher than that of the control group(71.67%),and the difference was statistically significant(χ^(2)=4.093,P<0.05).Af-ter treatment,compared with the control group,the observation group had lower levels of interleukin-6(IL-6)and high sensitive C-reactive protein(hs-CRP),and the differences were statistically significant(both P<0.05).Conclu-sion Leech can effectively reduce the clinical symptoms of patients with cognitive impairment caused by CSVD and improve the cognitive dysfunction of patients.