咪唑斯汀治疗急慢性荨麻疹并发过敏性鼻炎的可行性分析

Feasibility Analysis of Mizolastine in the Treatment of Acute and Chronic Urticaria Complicated with Allergic Rhinitis

目的分析咪唑斯汀治疗急慢性荨麻疹并发过敏性鼻炎的可行性。方法回顾性选取2020年2月—2021年2月山东省临朐县人民医院耳鼻喉科收治的100例急慢性荨麻疹并发过敏性鼻炎患者的临床资料,依据用药方法分为咪唑斯汀组、西替利嗪组,各50例。咪唑斯汀组口服咪唑斯汀、西替利嗪组口服西替利嗪。比较两组的风团数、风团直径评分、症状评分、生活质量、临床疗效、不良反应发生情况、复发情况。结果用药前,两组风团数、风团直径评分、瘙痒、鼻痒、鼻塞、打喷嚏、流涕评分、生活质量评分比较,差异无统计学意义(P均>0.05),用药后,两组的风团数、风团直径评分、瘙痒、鼻痒、鼻塞、打喷嚏、流涕评分均低于用药前,且咪唑斯汀组低于西替利嗪组,差异有统计学意义(P均<0.05);用药后,生活质量评分均高于用药前,且咪唑斯汀组高于西替利嗪组,差异有统计学意义(P均<0.05);咪唑斯汀组的总有效率为96.00%,高于西替利嗪组的80.00%,差异有统计学意义(χ^(2)=6.061,P<0.05)。咪唑斯汀组患者的不良反应发生率和复发率均低于西替利嗪组,差异有统计学意义(P均<0.05)。结论咪唑斯汀治疗急慢性荨麻疹并发过敏性鼻炎的可行性较高。

Objective To analyze the feasibility of mizolastine in the treatment of acute and chronic urticaria complicated with allergic rhinitis.Methods The clinical data of 100 patients with acute and chronic urticaria and allergic rhinitis admitted to the otolaryngology department of Linqu County People's Hospital,Shandong Province from February 2020 to February 2021 were retrospectively selected,according to the medication method,they were divided into mizolastine group,cetirizine group,50 cases each.Mizostine group oral cizostine and cetirizine group oral cetirizine.The number of wind groups,wind group diameter score,symptom score,quality of life,clinical efficacy,adverse effects,and recurrence of the two groups were compared.Results Before medication,there was no statistically significant difference in the number of wind groups,wind group diameter score,itching,nasal itching,nasal congestion,sneezing,runny nose score between the two groups(all P>0.05).After medication,the number of wind groups,wind diameter score,itching,nasal itching,nasal congestion,sneezing and runny nose of the two groups were lower than before medi-cation,and the mizolastine group was lower than cetirizine group,the differences were statistically significant(all P<0.05).After medication,the quality of life score was higher than before medication,and the mizastine group was higher than cetirizine group,the difference was statistically significant(all P<0.05).The overall response rate in mizos-tine group was 96.00%which was higher than 80.00%in cetirizine group,the difference was statistically significant(χ^(2)=6.061,P<0.05).The incidence of adverse reactions and recurrence in midazastine group were lower than those in cetirizine group,and the difference was statistically significant(both P<0.05).Conclusion The feasibility of imidazoas-tine for acute and chronic urticaria complicated by allergic rhinitis is high.