阿奇霉素联合特布他林对支原体肺炎患儿体液免疫及炎症水平的影响

Effects of Azithromycin Combined with Terbutaline on Humoral Immunity and Inflammation Level in MPP Children

目的阿奇霉素联合特布他林对支原体肺炎(MPP)患儿体液免疫及炎症水平的影响。方法选取2020年3月-2021年3月在本院确诊的98例MPP患儿,随机把所有患儿分成观察组、对照组,各49例,对照组采用阿奇霉素治疗,观察组采用阿奇霉素联合特布他林进行治疗,均持续治疗14d。比较两组患儿临床疗效、临床症状、体液免疫及炎症水平。结果观察组治疗的有效率明显高于对照组的有效率(χ^(2)=4.346,P=0.037);观察组患儿各种症状消失和住院时间均更短(P<0.05)。治疗后两组患儿免疫球蛋白A(IgA)、免疫球蛋白G(IgG)均低于治疗前,但观察组高于对照组(P<0.05)。治疗后两组患儿血清白细胞介素-6(IL-6)、超敏C反应蛋白(CRP)水平均低于治疗前,且观察组低于对照组(P<0.05)。结论阿奇霉素联合特布他林临床疗效较好,可以改善MPP患儿体液免疫及炎症水平。

Objective To explore the effects of azithromycin combined with terbutaline on humoral immunity and inflammation level in children with Mycoplasma pneumoniae pneumonia(MPP).Methods A total of 98 children with MPP confirmed in the hospital were enrolled between March 2020 and March 2021.They were randomly divided into observation group and control group,in 49 cases in each group.The control group was treated with azithromycin,while observation group was additionally treated with terbutaline.All were continuously treated for 14d.The clinical curative effect,clinical symptoms,humoral immunity and inflammation level were compared between the two groups.Results The response rate of treatment in observation group was significantly higher than that in control group(χ^(2)=4.346,P=0.037).The disappearance time of symptoms and hospitalization time in observation group were significantly shorter than those in control group(P<0.05).After treatment,levels of immunoglobulin A(IgA)and immunoglobulin G(IgG)in both groups were decreased,which were higher in observation group than control group(P<0.05).After treatment,levels of serum interleukin-6(IL-6)and high-sensitivity C-reactive protein(CRP)in both groups were decreased,which were lower in observation group than control group(P<0.05).Conclusion The clinical curative effect of azithromycin combined with terbutaline is good,which can improve humoral immunity and inflammation level in MPP children.