血清AST、ALT、ESR及IL-21预测系统性红斑狼疮肝损伤的价值

Value of Serum AST,ALT,ESR,and IL-21 in Predicting Liver Injury in Systemic Lupus Erythematosus

目的探究血清天门冬氨酸基转移酶(AST)、丙氨酸氨基转移酶(ALT)、红细胞沉降率(ESR)及白介素-21(IL-21)预测系统性红斑狼疮肝损伤的价值。方法选取2020年3月-2022年3月我院收治的80例系统性红斑狼疮患者作为研究对象,根据是否发生肝损伤分为肝损伤组和未损伤组,获取患者临床资料,分析脂血清AST、ALT、ESR及IL-21的预测价值。结果经logistic回归分析显示,AST、ALT、ESR、IL-21是系统性红斑狼疮肝损伤独立影响因素(P<0.05)。经ROC曲线分析显示:当AST、ALT、ESR、IL-21截断值分别为(194.64)、(0.794)、(17.64)、(119.56)时可获得最佳预测效能,此时AUC为0.899(95%CI:0.866~0.932),敏感度为(92.26),特异度为(80.64)、约登指数为(0.618)。结论血清AST、ALT、ESR及IL-21是系统性红斑狼疮肝损伤影响因素,4项联合检测可提高对肝损伤预测价值。

Objective To investigate the value of serum aspartate transferase(AST),alanine aminotransferase(ALT),erythrocyte sedimentation rate(ESR)and interleukin-21(IL-21)in predicting systemic lupus erythematosus liver injury.Methods A total of 80 patients with systemic lupus erythematosus admitted to our hospital from March 2020 to March 2022 were selected as research subjects,and they were divided into liver injury group and non-injury group according to whether liver injury occurred,and the clinical data of patients were obtained,and the predictive value of lipid serum AST,ALT,ESR and IL-21 was analyzed.Results Logistic regression analysis showed that AST,ALT,ESR,and IL-21 were independent influencing factors of liver injury in systemic lupus erythematosus(P<0.05).According to ROC curve analysis,the best predictive performance can be achieved when the cutoff values of AST,ALT,ESR,and IL-21 are(194.64),(0.794),(17.64),and(119.56),respectively.At this time,the AUC is 0.899(95%CI:0.866~0.932),the sensitivity is(92.26),the specificity is(80.64),and the Jordan index is(0.618).Conclusion Serum AST,ALT,ESR and IL-21 are the influencing factors of systemic lupus erythematosus liver injury,and the combination of four tests can improve the predictive value of liver injury.