性激素水平对青少年非自杀性自伤行为的影响

目的 探讨性激素水平对青少年非自杀性自伤(NSSI)的影响,以及性激素水平与HAMD-24各因子评分的相关性。方法 选取符合DSM-5的非自杀性自伤行为的青少年患者95例(NSSI组);同期健康体检的青少年78例为CN组(CN组),收集人口学资料及各组患者血清促卵泡素(FSH)、促黄体素(LH2)、雌二醇(E2)、催乳素(PRL)、孕酮(P)和睾酮(T)水平。比较两组一般资料及性激素水平,并分析单相抑郁症、双相抑郁症性激素水平与HAMD-24各因子评分的相关性。结果 NSSI组与CN组血清E2、PRL、P、T水平比较,差异均有统计学意义(P<0.05);单相抑郁组与双相抑郁组性激素水平比较,差异无统计学意义(P>0.05)。NSSI组PRL水平与HAMD-24体质量因子呈正相关,单相抑郁症患者血清E2水平与HAMD-24日夜变化评分呈负相关。结论 青少年NSSI可能与血清E2、PRL、P、T水平变化相关。E2、PRL、P水平升高及T水平降低可能对青少年NSSI产生影响。

Objective To explore the effect of sex hormone levels on adolescent non-suicidal self-injury behavior(NSSI)and the correlation between sex hormone levels and Hamilton Depression Scale 24-item score(HAMD-24).Methods A total of 95 adolescent patients with DSM-5 NSSI were selected as the NSSI group.During the same period,78 healthy adolescents who underwent physical examination in hospital were selected as the CN group.The demographic data and the levels of follicle-stimulating hormone(FSH),luteinizing hormone(LH2),estradiol(E2),prolactin(PRL),progesterone(P)and testosterone(T)in each group were collected.The general data and the sex hormone level in peripheral blood of NSSI group and CN group were compared,and the correlation between sex hormone level in peripheral blood of monophasic depression and bipolar depression patients and HAMD-24 score was analyzed respectively.Results E2,PRL,P,and T showed significant difference between the NSSI group and the healthy control group(P<0.05),and there was no significant difference in sex hormone level in peripheral blood between monophasic depression group and bipolar depression group(P>0.05).There was a positive correlation between PRL level and weight factor of HAMD-24 score in the NSSI group.The level of E2 in peripheral blood of patients with monophasic depression was negatively correlated with diurnal variation of HAMD-24 score.Conclusion Changes in the incidence of adolescent NSSI and E2,PRL,P,T level has relationship.The increase of E2,PRL and P levels and the decrease of T level in peripheral blood may have an impact on NSSI in adolescents.