PAPP-A、Free-β-HCG与子痫前期的相关性分析

目的 探讨妊娠相关血浆蛋白A(PAPP-A)、游离β-人绒毛膜促性腺激素(Free-β-HCG)与子痫前期的相关性。方法 收集2021年1月至2023年1月548例有妊娠结局且孕期行血清学筛查孕妇的临床资料。依据是否发生子痫分为子痫前期组与正常孕妇组,分析两组孕妇一般资料及血清学筛查指标。结果 子痫前期组孕妇PAPP-A低于正常孕妇组,差异有统计学意义(P<0.05);而子痫前期组孕妇Free-β-HCG与正常孕妇组比较,差异无统计学意义(P<0.05);PAPP-A、Free-β-HCG用于筛查子痫前期的ROC曲线下面积为0.603、0.548。结论 血清学筛查指标PAPP-A与子痫前期密切相关,其可作为预测子痫前期发生的指标。

Objective To investigate the correlation between serological screening indicators pregnancy-associated plasma protein A(PAPP-A)and free human villus gonadotropinβ(Free-β-HCG)and preeclampsia.Methods A retrospective study was used in this study.Pregnant women with pregnancy outcomes and serological screening in the Maternal and Child Health Hospital of Inner Mongolia Autonomous Region from January 2021 to January 2023 were selected as subjects.General information and serological screening data of the subjects were collected and sorted out,and SPSS26.0 statistical software was used to process the data.Results Serological screening index PAPP-A in the preeclampsia group was significantly correlated with preeclampsia,and PAPP-A was lower than that in the normal pregnant women group,the difference was statistically significant.The serological screening index of Free-β-HCG in the preeclampsia group was lower than that in the normal pregnant women group,and the difference was not statistically significant.The area under the ROC curve of serological screening indexes PAPP-A and Free-β-HCG for screening for preeclampsia were 0.603 and 0.548,respectively.Conclusion Serological screening index PAPP-A is closely related to preeclampsia,which can be used as a predictor to detect the occurrence of preeclampsia early.