回旋加速器制备^(89)Zr及其纯化和标记研究

Preparation of ^(89)Zr by Cyclotron and its Purification and Labeling Methods

为了获得高质量^(89)Zr核素用于核医学显像,利用HM-20S型回旋加速器辐照^(89)Y靶制备^(89)Zr,对核反应激发函数进行了计算,设计了靶系统并制备靶片通过回旋加速器辐照制备^(89)Zr,对靶片放化分离方法和^(89)Zr标记工艺进行了研究。结果表明,回旋加速器制备^(89)Zr最佳束流能量为9~13.5 MeV,其中在13.5 MeV能量处获得最大反应截面。回旋加速器束流引出为14 MeV,经真空膜和靶膜衰减后剩余能量约为12.86 MeV,束流在^(89)Y靶中呈高斯分布,射程约为0.821 mm。^(89)Y靶片经15μA束流辐照1.50~3.33 h,得到轰击结束时^(89)Zr活度为22.20~85.45 mCi,产额约为36.51~63.30 MBq/(μA·h)。采用UTEVA树脂从辐照后的靶片中分离^(89)Zr,^(89)Zr回收率为86.27%,Y(Ⅲ)去除率为99.80%。^(89)Zr-DFO-NCS标记化合物放化纯度>98%,标记效果良好。

In order to obtain high quality ^(89)Zr nuclide for nuclear medicine imaging,^(89)Zr was produced by irradiating ^(89)Y with HM-20S cyclotron.The nuclear reaction excitation function was calculated.The target system was designed and the target was prepared.^(89)Zr was prepared by irradiating target with cyclotron.The radiochemical separation method of the target and the ^(89)Zr labeling process were studied.The results show that the optimum energy range of ^(89)Zr beam produced by cyclotron was 9-13.5 MeV,while,the maximum reaction cross section was 13.5 MeV energy.The extracted beam current of the cyclotron is 14 MeV,and the residual energy is about 12.86 MeV after attenuation by the vacuum film and the target film.The beam has a Gaussian distribution in the ^(89)Y target,and the range is approximately 0.821 mm.The activity of ^(89)Zr at the end of bombardment was 22.20-85.45 mCi and the yield was about 36.51-63.30 MBq/(μA·h)when^(89)Y target was irradiated with 15μA beam for 1.50-3.33 h.UTEVA resin was used to separate ^(89)Zr from the irradiated target.The recovery rate of ^(89)Zr was 86.27%,and the removal rate of Y(Ⅲ)was 99.80%.Successful ^(89)Zr-DFO-NCS labeling was performed with a radiochemical purity of more than 98%.