双酚类化合物的生物代谢机理研究进展

Research progresses of biotransformation mechanisms of bisphenols

以双酚A(bisphenol A,简称BPA)及其替代物为代表的双酚类化合物(bisphenols,简称BPs)在各种环境介质、食品、消费品以及人类和动物体中被广泛检出,表明BPs存在全球性大规模污染趋势.除了BPs自身毒性外,其在生物体内的转化代谢产物可能具有比母体化合物更复杂的内分泌干扰效应和毒性效应,对于人体生命健康的影响不容小觑.本文就BPs生物代谢的实验和理论计算研究方法及其取得的研究成果等方面进行回顾总结,在分析现有研究存在的问题和不足上对未来的研究重点提出了展望.

Bisphenol A(BPA)and its substitutes,as representatives of phenolic compounds(BPs),have been widely detected in various environmental media,foods,consumer products,and human and animal bodies,indicating a pervasive global contamination trend.Beyond their inherent toxicity,BPs’transformation metabolites within organisms may exhibit more complex endocrine-disrupting and toxic effects than the parent compounds,with significant implications for human health.This paper presents a comprehensive review and summary of experimental and theoretical research methods employed in studying the biotransformation of BPs,along with the corresponding research findings.Furthermore,by examining the existing limitations and deficiencies in current studies,the paper provide insight into future research priorities.The elucidation of BPs'biological metabolism and its implications contributes to a better understanding of their potential risks and aids in the development of effective strategies for mitigating their adverse effects.