小儿豉翘清热颗粒联合奥司他韦治疗儿童甲型H1N1流感的效果及对免疫功能的影响

Effect of Xiao’er Chiqiaoqingre Granules Combined with Oseltamivir in the Treatment of Influenza A(H1N1)in Children and Its Influence on Immune Function

目的:观察小儿豉翘清热颗粒联合奥司他韦治疗儿童甲型H1N1流感的效果及对免疫功能的影响。方法:选择2021年1月—2023年1月于宿迁市第一人民医院就诊的102例甲型H1N1流感患儿作为研究对象,采用随机数表法将其分为常规组(n=51)与中药组(n=51)。两组均给予一般治疗与护理,常规组给予口服磷酸奥司他韦治疗,中药组在常规组基础上给予小儿豉翘清热颗粒口服治疗。比较两组临床疗效、中医症候积分、T淋巴细胞亚群水平与不良反应。结果:中药组治疗总有效率为96.08%,高于常规组的82.35%,差异有统计学意义(P<0.05);治疗后,两组主症、次症积分较治疗前降低,且中药组低于常规组,差异有统计学意义(P<0.05);治疗后,两组CD3^(+)、CD4^(+)与CD4^(+)/CD8^(+)较治疗前升高,且中药组高于常规组,CD8^(+)较治疗前降低,且中药组低于常规组,差异有统计学意义(P<0.05);中药组不良反应发生率为7.84%,高于常规组的3.92%,但差异无统计学意义(P>0.05)。结论:小儿豉翘清热颗粒与奥司他韦联合使用可以有效治疗儿童甲型H1N1流感,缓解临床症状,提高免疫功能,且安全性较高。

Objective:To observe the effect of Xiao’er Chiqiaoqingre Granules combined with Oseltamivir in the treatment of influenza A(H1N1)in children and its influence on immune function.Method:A total of 102 children with influenza A(H1N1)who treated in the First People's Hospital of Suqian from January 2021 to January 2023 were selected as the study objects,and they were divided into the conventional group(n=51)and the traditional Chinese medicine group(n=51)by random number table method.Two groups were given general treatment and nursing,the conventional group was given oral Oseltamivir Phosphate treatment,and the traditional Chinese medicine group was given oral Xiao’er Chiqiaoqingre Granules treatment on the basis of the conventional group.The clinical efficacy,traditional Chinese medicine syndrome score,T lymphocyte subsets and adverse reactions were compared between two groups.Result:The total effective rate of the traditional Chinese medicine group was 96.08%,which was higher than 82.35%of the conventional group,and the difference was statistically significant(P<0.05).After treatment,the main and secondary syndrome scores of two group were lower than those before treatment,those in the traditional Chinese medicine group were lower than than those in the conventional group,and the differences were statistically significant(P<0.05).After treatment,CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)of two group were higher than those before treatment,those in the traditional Chinese medicine group were higher than than those in the conventional group,CD8^(+)of two group were lower than those before treatment,and that in the traditional Chinese medicine group was lower than that in the conventional group,the differences were statistically significant(P<0.05).The incidence of adverse reactions in the traditional Chinese medicine group was 7.84%,which was higher than 3.92%in the conventional group,but the difference was not statistically significant(P>0.05).Conclusion:Combination of Xiao’er Chiqiaoqingre Granules combined with Oseltamivir can effectively treat influenza A(H1N1)in children,relieve clinical symptoms,improve immune function,and has high safety.