基于肠道菌群探讨糖尿病周围神经病变的研究概况

Study on Diabetic Peripheral Neuropathy Based on Intestinal Flora

糖尿病(DM)已经成为全球增长最快的公共卫生问题之一,其周围神经并发症的发病率亦随之增长,然而就目前临床诊疗效果来看,结果未能令人满意。随着对糖尿病周围神经病变(DPN)的深入研究及人类宏基因组学的发展,越来越多的医学证据表明,DPN患者的肠道微生物组群或功能发生了变化。在此基础上,研究者们提出和证实了一些肠道菌群参与DPN发病的机制,及基于恢复肠道菌群组成结构和功能的治疗糖尿病周围神经并发症的新型治疗方法。本文将对肠道菌群在DPN发病机制中的作用,及基于肠道菌群理论进行相关干预措施的研究进展进行综述。

Diabetes mellitus(DM)has become one of the fastest growing public health problems in the world,and the incidence rate of its peripheral nerve complications has also increased,but the results are not satisfactory in terms of clinical diagnosis and treatment effect.With the in-depth study of diabetes peripheral neuropathy and the development of human metagenomics,more and more medical evidence shows that the intestinal microbiome or function of patients with diabetes peripheral neuropathy has changed.On this basis,the researchers proposed and confirmed the mechanism of some intestinal flora participating in the pathogenesis of diabetes peripheral neuropathy,and a new treatment method for diabetes peripheral neuropathy based on restoring the composition,structure and function of intestinal flora.This article will review the role of intestinal flora in the pathogenesis of diabetes peripheral neuropathy,and the research progress of relevant intervention measures based on intestinal flora theory.