仙灵骨葆胶囊对骨质疏松性腰椎骨折PVP后患者的影响

Effect of Xianling Gubao Capsules on Patients with Osteoporotic Lumbar Fracture after PVP

目的:探讨仙灵骨葆胶囊对骨质疏松性腰椎骨折经皮椎体成形术(PVP)后患者的影响。方法:选取2022年2月—2023年1月莆田九十五医院收治的93例骨质疏松性腰椎骨折PVP术后患者。根据入院单尾号将其分为对照组(47例,单号)和研究组(46例,双号)。对照组给予常规治疗,研究组在对照组基础上给予仙灵骨葆胶囊。比较两组治疗前、治疗3个月疼痛程度、骨密度、椎体前缘高度与Cobb角、骨代谢指标、炎症因子、腰椎功能。结果:治疗3个月,研究组视觉模拟评分法(VAS)评分、Cobb角较对照组低,骨密度、椎体前缘高度较对照组高,差异有统计学意义(P<0.05)。治疗3个月,研究组骨钙素(BGP)、骨碱性磷酸酶(BALP)水平较对照组高,白细胞介素-17(IL-17)、白细胞介素-1β(IL-1β)水平较对照组低,差异有统计学意义(P<0.05)。治疗3个月,研究组Oswestry功能障碍指数(ODI)评分较对照组低,差异有统计学意义(P<0.05)。结论:骨质疏松性腰椎骨折PVP后患者采用仙灵骨葆胶囊治疗可减轻疼痛程度,提高骨密度,改善椎体前缘高度与Cobb角,调节骨代谢,降低炎症指标水平,提升腰椎功能。

Objective:To explore the effect of Xianling Gubao Capsules on patients with osteoporotic lumbar fracture after percutaneous vertebroplasty(PVP).Method:A total of 93 patients with osteoporotic lumbar fracture after PVP were selected from February 2022 to January 2023 in Putian 95 Hospital.The patients were divided into control group(47 cases,single number)and study group(46 cases,even number)according to the end number of admission slips.The control group was given conventional treatment,and the study group was given Xianling Gubao Capsules on the basis of the control group.Pain degree,bone mineral density,vertebral anterior margin height,Cobb angle,bone metabolism index,inflammatory factors and lumbar function were compared between the two groups before treatment and at 3 months of treatment.Result:After 3 months of treatment,the visual analogue scale(VAS)score,Cobb angle of the study group were lower than those of the control group,the bone density and anterior vertebral height of the study group were higher than those of the control group,and the differences were statistically significant(P<0.05).After 3 months of treatment,the levels of osteocalcin(BGP)and bone alkaline phosphatase(BALP)in the study group were higher than those in the control group,the levels of interleukin-17(IL-17)and interleukin-1β(IL-1β)were lower than those of the control group,and the differences were statistically significant(P<0.05).After 3 months of treatment,the Oswestry dysfunction index(ODI)score of the study group was lower than that of the control group,and the difference was statistically significant(P<0.05).Conclusion:Xianling Gubao Capsules can reduce pain degree,increase bone mineral density,improve vertebral anterior margin height and Cobb angle,regulate bone metabolism,reduce inflammation index level,and improve lumbar function after PVP in patients with osteoporotic lumbar fracture.