硫酸镁联合布地奈德治疗哮喘患儿的效果

Treatment of Children with Asthma

目的:探讨硫酸镁联合布地奈德治疗哮喘患儿的效果。方法:选取2020年2月—2023年2月南宁市第二人民医院儿科收治的90例哮喘患儿。根据随机数字排序将其分为治疗组与基础组,各45例。基础组给予布地奈德治疗,治疗组在基础组基础上给予硫酸镁注射液。比较两组临床疗效,治疗前后肺功能、血气指标、哮喘情况、炎症因子及镁离子水平。结果:治疗组总有效率高于基础组,差异有统计学意义(P<0.05)。治疗后,两组用力肺活量(FVC)、呼气峰流速(PEF)、第1秒用力呼气容积(FEV_(1))占预计值的百分比(FEV_(1)%pred)、FEV_(1)均升高,治疗组FVC、PEF、FEV_(1)%pred、FEV_(1)均高于基础组,差异有统计学意义(P<0.05)。治疗后,两组血氧分压(PaO_(2))、酸碱度(pH)、血氧饱和度(SaO_(2))均升高,二氧化碳分压(PaCO_(2))降低,治疗组PaO_(2)、pH、SaO_(2)均高于基础组,PaCO_(2)低于基础组,差异有统计学意义(P<0.05)。治疗后,两组儿童哮喘控制测试评分表(C-ACT)评分、镁离子水平均升高,白细胞介素-1(IL-1)、肿瘤坏死因子-α(TNF-α)、白细胞介素-5(IL-5)水平均降低,治疗组C-ACT评分、镁离子水平均高于基础组,IL-1、TNF-α、IL-5水平均低于基础组,差异有统计学意义(P<0.05)。结论:硫酸镁联合布地奈德对哮喘患儿的治疗效果较好,且明显优于单一激素治疗,能够显著改善患儿的临床症状,对炎症因子、血气指标、肺功能等哮喘相关指标的改善作用明显。

Objective:To explore the effect of Magnesium Sulfate combined with Budesonide in the treatment of children with asthma.Method:A total of 90 children with asthma admitted to the Department of Pediatrics of the Nanning Second People's Hospital from February 2020 to February 2023 were selected.They were divided into treatment group and basic group according to random number ordering,45 cases in each group.The basic group was given Budesonide treatment and the treatment group was given Magnesium Sulfate Injection on the basis of the basic group.The clinical efficacy,lung function,blood gas index,asthma condition,inflammatory factors and magnesium ion level before and after treatment were compared between the two groups.Result:The total effective rate of the treatment group was higher than that of the basic group,and the difference was statistically significant(P<0.05).After treatment,the forced vital capacity(FVC),peak expiratory flow rate(PEF),the percentage of forced expiratory volume in one second(FEV_(1))to the predicted value(FEV_(1)%pred)and FEV_(1)in the two groups were increased,and the FVC,PEF,FEV_(1)%pred and FEV_(1)in the treatment group were higher than those in the basic group,the differences were statistically significant(P<0.05).After treatment,the blood oxygen partial pressure(PaO_(2)),pH(pH)and blood oxygen saturation(SaO_(2))of both groups were increased,while the partial pressure of carbon dioxide(PaCO_(2))were decreased,PaO_(2),pH and SaO_(2)of the treatment group were higher than those of the basic group,and PaCO_(2)was lower than that of the basic group,the differences were statistically significant(P<0.05).After treatment,the asthma control test score(C-ACT)and magnesium ion level were increased in the two groups,while the levels of interleukin-1(IL-1),tumor necrosis factor-α(TNF-α)and interleukin-5(IL-5)were decreased in the two groups,the C-ACT score and magnesium ion level in the treatment group were higher than those in the basic group,the levels of IL-1,TNF-αand IL-5 were lower than those of basic group,and the differences were statistically significant(P<0.05).Conclusion:Magnesium Sulfate combined with Budesonide has a good therapeutic effect on children with asthma,and is obviously better than single hormone therapy,which can significantly improve the clinical symptoms of children with asthma,and has obvious improvement effects on inflammatory factors,blood gas indexes,lung function and other asthma-related indicators.