舒芬太尼PCIA复合艾司氯胺酮对胸腔镜下肺癌根治术患者疼痛及疲劳水平的影响

Effect of Sufentanil PCIA Combined with Esketamine on Pain and Fatigue Levels in Patients Undergoing Thoracoscopic Radical Resection of Lung Cancer

目的:观察舒芬太尼自控静脉镇痛(PCIA)复合艾司氯胺酮对胸腔镜下肺癌根治术患者疼痛及疲劳水平的影响。方法:选择2022年4月—2023年4月莆田市第一医院收治的82例肺癌患者作为研究对象,随机将其分为两组,各41例。对照组给予舒芬太尼PCIA,观察组给予舒芬太尼PCIA复合艾司氯胺酮。比较两组术后不同时点疼痛评分、疲劳状况评分及术后不良反应发生情况。结果:术后24 h、48 h、72 h,观察组视觉模拟评分法(VAS)评分、围手术期疲劳测评量表(ICFS)评分均低于对照组,差异有统计学意义(P<0.05)。两组头晕、嗜睡发生率比较,差异无统计学意义(P>0.05);观察组恶心呕吐、皮肤瘙痒发生率低于对照组,差异有统计学意义(P<0.05)。结论:舒芬太尼PCIA复合艾司氯胺酮可缓解胸腔镜下肺癌根治术患者术后疼痛程度,改善术后疲劳状况,且可减少术后不良反应的发生,安全性更高。

Objective:To observe the effects of Sufentanil patient-controlled intravenous analgesia(PCIA)combined with Esketamine on pain and fatigue levels in patients undergoing thoracoscopic radical resection for lung cancer.Method:A total of 82 patients with lung cancer admitted to the First Hospital of Putian City from April 2022 to April 2023 were selected as the study objects and randomly divided into two groups,with 41 cases in each group.The control group was given Sufentanil PCIA,and the observation group was given Sufentanil PCIA combined with Esketamine.The pain score,fatigue score at different time points and postoperative adverse reactions were compared between the two groups.Result:At 24 h,48 h and 72 h after operation,visual analogue scale(VAS)score,identity-consequence fatigue scale(ICFS)score in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).There were no significant differences in the incidence of dizziness and lethargy between the two groups(P>0.05).The incidence of nausea,vomiting and pruritus in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion:Sufentanil PCIA combined with Esketamine can relieve postoperative pain,improve postoperative fatigue,and reduce postoperative adverse reactions in patients undergoing thoracoscopic radical resection for lung cancer surgery,with higher safety.