早产儿喂养不耐受与肠道菌群关系的研究进展

Research Progress on Relationship between Feeding Intolerance and Gut Microbiota in Premature Infants

早产儿在母体内成长时间不足,受多种因素影响提前娩出,但早产儿机体内部组织、器官、系统存在发育不成熟的问题,因此在临床上需要特殊护理和喂养。早产儿喂养不耐受(feeding intolerance,FI)是较常见的现象,这与早产儿胃肠功能不全、胃动力不足、肠道菌群失调等紧密相关。其中肠道菌群结构失衡及不同微生物的定植均会对早产儿的胃肠道功能造成影响,明确早产儿FI与肠道菌群之间的关系有助于早产儿肠胃功能调理与治疗,解决早产儿FI问题,促进其健康发育和成长。本文将介绍早产儿FI的诊断标准,针对FI及肠道菌群的关系进行综述,提出改善早产儿FI情况的方法,以供参考。

The growth time of premature infants in the mother is insufficient,and they are delivered early due to various factors,however,the internal tissues,organs and systems of premature infants are immature,so special nursing and feeding are needed clinically.Feeding intolerance(FI)in preterm infants is a common phenomenon,which is closely related to gastrointestinal insufficiency,gastric motility insufficiency,gut microbiota imbalance in preterm infants.The imbalance of gut microbiota structure and the colonization of different microorganisms will affect the gastrointestinal function of preterm infants,clarifying the relationship between FI and gut microbiota of preterm infants will help regulate and treat the gastrointestinal function of preterm infants,solve the problem of FI of preterm infants,and promote their healthy development and growth.This article introduced the diagnostic criteria of FI of preterm infants,reviewed the relationship between FI and gut microbiota,and proposed methods to improve FI of preterm infants for reference.