谷红注射液联合尼麦角林治疗急性脑梗死的效果及对神经功能恢复、血管内皮功能的影响

Effect of Guhong injection combined with nicergoline in the treatment of acute cerebral infarction and its influence on neurological function recovery and vascular endothelial function

目的探讨谷红注射液联合尼麦角林治疗急性脑梗死的效果及对神经功能恢复、血管内皮功能[血管内皮生长因子(VEGF)、血栓素-A2(TX-A2)、内皮素-1(ET-1)、一氧化氮(NO)]、血液流变学(红细胞压积、血浆粘度、血小板聚集率、纤维蛋白原)变化,比较治疗期间不良反应发生情况。方法接受治疗的128例急性脑梗死患者,随机分为观察组和对照组各64例,两组患者均给与常规治疗,对照组给与尼麦角林治疗,观察组给与谷红注射液联合尼麦角林治疗。治疗2周后,评估两组患者临床疗效;比较治疗前和治疗2周后两组患者神经功能恢复[神经功能缺损评分量表(NIHSS)、Barthel指数量表(BI)]、血管内皮功能[血管内皮生长因子(VEGF)、血栓素-A2(TX-A2)、内皮素-1(ET-1)、一氧化氮(NO)]、血液流变学变化(红细胞压积、血浆粘度、血小板聚集率、纤维蛋白原),比较治疗期间不良反应发生情况。结果治疗2周后,观察组总有效率高于对照组(P<0.05);两组患者NIHSS评分、血管内皮因子(VEGF、ET-1、NO、TX-A2)水平及血液流变学(红细胞压积、血浆粘度、血小板聚集率、纤维蛋白原)水平较治疗前降低,且观察组低于对照组(P<0.05);BI评分较治疗前升高,且观察组高于对照组(P<0.05)。两组不良反应差异无显著性(P>0.05)。结论谷红注射液联合尼麦角林治疗急性脑梗死效果显著,可促进神经功能恢复,提高血管内皮功能,改善血液流变学状态。

Aim To explore the effect of Guhong injection combined with nicergoline in the treatment of acute cerebral infarction and the influence on neurologicalfunction recovery and vascular endothelial function.Methods 128 patients with acute cerebral infarction who received treatment were included and randomly divided into observation group(n=64)and control group(n=64),patients in both groups were given conventional treatment,and the control group was treated with nicergoline,and the observation group was given Guhong injection combined with nicergoline.After 2 weeks of treatment,the clinical efficacy of the two groups was e valuated.Neurological function recovery[National Institutes of Health Stroke Scale(NIHSS),Barthel Index(BI)],vascular endothelial function[vascular endothelial growth factor(VEGF),thromboxane-A2(TX-A2),endothelin-1(ET-1),nitric oxide(NO)]and hemorheology(hematokrit,plasma viscosity,platelet aggregation rate,fibrinogen)were compared between the two groups before treatment and after 2 weeks of treatment,and the adverse reactions during treatment were counted.Results After 2 weeks of treatment,the total effective rate in observation group was higher than that in control group(P<0.05).The NIHSS score,vascular endothelial factors(VEGF,ET-1,NO,TX-A2)and hemorheology(hematocrit,plasma viscosity,platelet aggregation rate,fibrinogen)in both groups were decreased compared with those before treatment,and the above indicators in observation group were lower compared with those in control group(all P<0.05).BI score was enhanced compared to before treatment,and the score in observation group was higher than that in control group(P<0.05).There is no significant difference in adverse reactions between the two groups(P>0.05).Conclusion Guhong injection combined with nicergoline has a significant effect in the treatment of acute cerebral infarction,and it can promote the recovery ofneurologicalfunction,enhance the vascular endothelial function and improve the hemorheological status,and it does not increase the risk of adverse reactions.