lncRNA-miR210HG在NSCLC患者癌组织中的表达及其临床意义

Expression and clinical significance of lncRNA-miR210HG in cancer tissues of NSCLC patients

目的分析非小细胞肺癌(NSCLC)患者癌组织中长链非编码RNA(lncRNA)-miR210HG的表达及其临床意义。方法选取84例NSCLC患者,比较其癌组织及癌旁组织中lncRNA-miR210HG水平。按照lncRNA-miR210HG表达水平将患者分为高表达组和低表达组,比较两组临床病理参数和生存情况。多因素COX回归模型分析影响NSCLC患者预后的危险因素。结果NSCLC癌组织miR210和lncRNA-miR210HG表达水平均高于癌旁组织(P<0.05)。Ⅲ期、存在淋巴结转移的患者癌组织中lncRNA-miR210HG高表达者占比较高(P<0.05),高表达组总生存率和无进展生存率低于低表达组(P<0.05)。l ncRNA-miR210HG是影响NSCLC患者预后的独立危险因素(P<0.05)。结论NSCLC癌组织中lncRNA-miR210HG高表达与有无淋巴转移、临床分期有关,lncRNA-miR210HG是影响NSCLC患者预后的独立危险因素。

Aim To analyze the expression and clinical significance of long non-coding RNA(lncRNA)-miR210HG in cancer tissues of patients with non-small cell lung cancer(NSCLC).Methods A total of 84 patients with NSCLC were enrolled.The level of lncRNA-miR210HG in cancer tissues and para-carcinoma tissues was compared.According to average expression level of lncRNA-miR210HG,patients were divided into high-expression group and low-expression group,respectively,and clinicopathological parameters and survival in these two groups were compared.The risk factors affecting prognosis of NSCLC patients were analyzed by multivariate COX regression model.Results The expression levels of miR210 and lncRNA-miR210HG in cancer tissues were higher than those in para-carcinoma tissues(P<0.05).The proportion of high-expression lncRNA-miR210HG was higher in patients with clinical staging at stage III and lymph node metastasis(P<0.05).The overall survival rate and progression-free survival rate in high-expression group were lower than those in low-expression group(P<0.05).The lncRNA-miR210HG was an independent risk factor to affect prognosis of NSCLC patients(P<0.05).Conclusion The high expression of lncRNA-miR210HG in cancer tissues is related to lymph node metastasis and clinical staging in NSCLC.The lncRNA-miR210HG is an independent risk factor to affect prognosis of NSCLC patients.