植物环肽研究进展

Advances on cyclopeptides of plants

植物环肽是一类主要由氨基酸肽键形成的环状含氮化合物,一般包含2~37个L-构型的编码或者非编码氨基酸结构单元,是具有重要研究价值的天然植物小分子代谢产物。科学研究表明,此类天然产物在各科植物中广泛分布,化学成分主要包括环二肽类、环四肽类、环五肽类、环六肽类、环七肽类、环八肽类、环九肽类、环十肽类等,其中环二肽类、环六肽类、环八肽类是其主要活性成分。据报道,植物环肽结构新奇、独特,具有抗肿瘤、抗菌、抗疟、抗炎、抗病毒等多种药理活性。该文对2006年以来植物环肽的研究成果进行了综述,以期为植物环肽及其在相关医药、卫生、农业等领域的进一步研究提供理论参考。

Cyclopeptides isolated from a variety of plants are a class of cyclic nitrogen-containing compounds,and they are primarily formed by peptide bonds between amino acids,generally containing 2 to 37 L-configuration encoded or non-encoded amino acid residues.Cyclopeptides have significant values in scientific research as natural small-molecule metabolites produced by plants.The available studies have revealed that such natural products are ubiquitous in plants,which mainly include cyclic dipeptides,cyclic tetrapeptides,cyclic pentapeptides,cyclic hexapeptides,cyclic heptapeptides,cyclic octapeptides,cyclic nonapeptides,and cyclic decapeptides.Among them,cyclic dipeptides,cyclic hexapeptides,and cyclic octapeptides are the major active compounds.It has been reported that plant cyclopeptides have novel and unique chemical structures.They possess diverse pharmacological activities,such as antineoplastic,antimicrobial,antimalarial,anti-inflammatory,and antiviral activities.This paper summarizes the research achievements of plant cyclopeptides since 2006,aiming to provide theoretical reference for the research and application of plant cyclopeptides in medicine,health,and agriculture fields.