摘要
采用大孔树脂、硅胶、葡聚糖凝胶、高效液相等色谱手段,对中药血竭的化学成分进行初步研究,分离得到1个反式二氢查耳酮类、4个黄烷类和1个二苯乙烯类化合物。通过现代波谱学、理化性质和文献比对鉴定其化学结构,分别鉴定为4-羟基-2,6-二甲氧基-3-甲基二氢查耳酮(1)、4′-羟基-5,7-二甲氧基-8-甲基黄烷(2)、7-羟基-4′,5-二甲氧基黄烷(3)、(2S)-7-羟基-5-甲氧基-6-甲基黄烷(4)、(2S)-7-羟基-5-甲氧基黄烷(5)、紫檀芪(6),其中化合物1为新化合物,化合物2和6为从棕榈科中首次分离得到。化合物5具有防治糖尿病肾脏疾病的潜力。
The chemical constituents of Draconis Sanguis were preliminarily studied by macroporous resin,silica gel,dextran gel,and high-performance liquid chromatography.One retro-dihydrochalcone,four flavonoids,and one stilbene were isolated.Their chemical structures were identified as 4-hydroxy-2,6-dimethoxy-3-methyldihydrochalcone(1),4′-hydroxy-5,7-dimethoxy-8-methylflavan(2),7-hydroxy-4′,5-dimethoxyflavan(3),(2S)-7-hydroxy-5-methoxy-6-methylflavan(4),(2S)-7-hydroxy-5-methoxyflavan(5),and pterostilbene(6)by modern spectroscopy,physicochemical properties,and literature comparison.Compound 1 was a new compound.Compounds 2 and 6 were first found in the Arecaceae family.Compound 5 had the potential to prevent and treat diabetic kidney disease.
作者
周露
段亚飞
王奕航
任尧
张效威
李汉伟
张振强
徐江雁
王潘
ZHOU Lu;DUAN Ya-fei;WANG Yi-hang;REN Yao;ZHANG Xiao-wei;LI Han-wei;ZHANG Zhen-qiang;XU Jiang-yan;WANG Pan(Academy of Chinese Medical Sciences,Henan University of Chinese Medicine,Zhengzhou 450046,China;College of Pharmacy,Henan University of Chinese Medicine,Zhengzhou 450046,China)
出处
《中国中药杂志》
CAS
CSCD
北大核心
2024年第5期1249-1254,共6页
China Journal of Chinese Materia Medica
基金
国家重点研发计划项目(2020YFE0201800)
河南省高校科技创新人才项目(23HASTIT044)
河南省科技攻关项目(232102310447)
河南省高校科技创新团队项目(21IRTSTHN026)。
关键词
血竭
化学成分
肾小管
糖尿病肾脏疾病
Draconis Sanguis
chemical constituent
renal tubule
diabetic kidney disease