腺叶切除术联合左旋甲状腺素治疗良性甲状腺结节的效果观察

Efficacy of lobectomy combined with levothyroxine in the treatment of benign thyroid nodules

目的探讨腺叶切除术联合左旋甲状腺素治疗良性甲状腺结节的临床效果。方法回顾性抽取2020年6月至2023年6月济南市第二人民医院收治的良性甲状腺结节患者78例,按照治疗方案分为对照组和研究组,每组39例。两组均行腺叶切除术,研究组在手术治疗基础上联合左旋甲状腺素治疗,比较两组治疗前后甲状腺功能[促甲状腺激素(TSH)、甲状腺素(FT4)、三碘甲状腺原氨酸(FT3)],比较两组治疗效果、并发症发生率及复发率。结果治疗前,两组甲状腺功能指标比较差异未见统计学意义(P>0.05);治疗后,两组FT3、FT4水平低于治疗前,TSH水平高于治疗前,差异有统计学意义(P<0.05);两组治疗后甲状腺功能指标比较差异未见统计学意义(P>0.05)。研究组总有效率(91.67%,38/39)高于对照组(79.49%,31/39),P<0.05。研究组并发症发生率、复发率低于对照组(P<0.05)。结论左旋甲状腺素联合腺叶切除术治疗良性甲状腺结节效果明显,可有效改善甲状腺功能,降低并发症发生率和复发率。

Objective To investigate the effect of lobectomy combined with levothyroxine in the treatment of benign thyroid nodules.Methods A total of 78 patients with benign thyroid nodules admitted to Ji’nan Second People’s Hospital from June 2020 to June 2023 were retrospectively selected,and they were divided into control group and study group according to the treatment plan,with 39 cases in each group.Both groups were treated by lobectomy.The study group was treated with levothyroxine based on the surgical treatment.The thyroid function evaluated by thyroid-stimulating hormone(TSH),thyroxine(FT4)and triiodothyronine(FT3)were compared between the two groups before and after treatment.The treatment effect,incidence of complication and recurrence rate of the two groups were compared.Results Before treatment,there was no significant difference in thyroid function indexes between the two groups(P>0.05).After treatment,the levels of FT3 and FT4 in the two groups were lower than those before treatment,and the levels of TSH in the two groups were higher than those before treatment(P<0.05).There was no significant difference in thyroid function indexes between the two groups after treatment(P>0.05).The total effective rate of the study group(91.67%,38/39)was higher than that of the control group(79.49%,31/39),P<0.05.The incidence of complications and recurrence rate of the study group were lower than those of the control group(P<0.05).Conclusions Levothyroxine combined with lobectomy has a significant effect in the treatment of benign thyroid nodules,which can effectively improve thyroid function and reduce the incidence of complications and recurrence.