TGF-β/Smad信号通路与急性白血病

TGF-β/Smad signal pathway and acute leukemia

转化生长因子β(TGF-β)/Smad信号通路是人体细胞内的一种重要的信号通路, 可调控细胞的生长、增殖与凋亡等生命活动, 其信号转导由配体与受体结合、细胞质内信号通路、细胞核内相互作用三部分组成。该信号通路与急性白血病的发病机制、耐药、复发及预后密切相关, 探究该信号通路的直接抑制剂、相关治疗靶点及天然提取物对白血病治疗的潜能, 可为研究白血病的生物标志物和靶向基因治疗提供新思路。

Transforming growth factor-β(TGF-β)/Smad signaling pathway is an important signaling pathway in human cells,which can regulate life activities such as cell growth,proliferation and apoptosis,and its signal transduction consists of ligand and receptor binding,intracytoplasmic signaling pathway,as well as interactions within the cell nucleus.This signaling pathway is closely related to the pathogenesis,drug resistance,recurrence and prognosis of acute leukemia.Exploring the potential of direct inhibitors,related therapeutic targets and natural extracts of this signaling pathway for the treatment of leukemia can provide new ideas for the study of biomarkers and targeted gene therapy for leukemia.