摘要
还原型烟酰胺腺嘌呤二核苷酸磷酸(NADPH)氧化酶2(Nox2)通过产生活性氧参与及影响人体正常生理功能。目前已发现Nox2在急性髓系白血病、胃癌、结直肠癌、卵巢癌、肺癌、食管癌中与患者的预后、肿瘤抗药性、分子靶向治疗等相关, 有可能是恶性肿瘤新的生物标志物及潜在的治疗靶点。
Reduced nicotinamide adenine dinucleotide phosphate(NADPH)oxidase 2(Nox2)acts as a source of reactive oxygen species,which participates in and influences normal physiological function of human body.Nowadays,many studies have found that Nox2 is related to prognosis of patients,drug resistance and molecular targeted therapy in various malignant tumors,such as acute myeloid leukemia,gastric cancer,colorectal cancer,ovarian cancer,lung cancer and esophageal cancer.What's more,it may be a novel biomarker and a potential therapeutic target for malignant tumors.
作者
刘小洁
黄俊星
Liu Xiaojie;Huang Junxing(Department of Oncology,Affiliated Jiangsu Taizhou People's Hospital of Nanjing Medical University,Jiangsu Taizhou People's Hospital,Taizhou 225300,China;Department of Clinical Medicine,Dalian Medical University,Dalian 116000,China)
出处
《国际肿瘤学杂志》
CAS
2023年第10期618-621,共4页
Journal of International Oncology
基金
江苏省卫生健康委科研项目(BJ20012)
江苏省医学创新团队项目(CXTDA2017042)
泰州市科技支撑计划(社会发展)项目(TS202001)。
关键词
NADPH氧化酶2
肿瘤
活性氧
抗药性
肿瘤
预后
NADPH oxidase 2
Neoplasms
Reactive oxygen species
Drug resistance,neoplasm
Prognosis
