摘要
ABRACL蛋白是肌动蛋白和细胞运动的调节因子,属于HSPC280家族,其保守的疏水槽可与其他蛋白相互作用,从而增强肌动蛋白动力和细胞活性。ABRACL在肿瘤组织中表达上调,与肿瘤细胞的增殖和迁移关系密切。深入了解ABRACL在肿瘤发生发展中的作用,可为ABRACL预防或逆转肿瘤进展提供新的思路和见解。
The ABRACL protein,the regulator of actin and cell motility,belongs to the HSPC280 family,and its conserved hydrophobic groove can interact with other proteins to facilitate actin motility and cellular activity.ABRACL is upregulated in tumor tissues and is closely linked with the proliferation and migration of tumor cells.A deeper understanding of the role of ABRACL in tumorigenesis and development may provide new ideas and insights for ABRACL to prevent or reverse tumor progression.
作者
叶彤彤
吴泽宇
席文一
王芝微
江晓春
赵晨辉
Ye Tongtong;Wu Zeyu;Xi Wenyi;Wang Zhiwei;Jiang Xiaochun;Zhao Chenhui(Department of Neurosurgery,First Affiliated Hospital of Wannan Medical College,Wuhu 241000,China)
出处
《国际肿瘤学杂志》
CAS
2023年第9期544-547,共4页
Journal of International Oncology
基金
安徽省教育厅自然科学重点项目(2022AH051250)
安徽省高校优秀科研创新团队项目(2022AH010073)
芜湖市科技局应用基础研究项目(2022JC69)
皖南医学院中青年研究基金(WK2021F22)。
