细胞外囊泡DNA作为肿瘤液体活检分子的指标价值

Value of extracellular vesicle DNA as an indicator of tumor liquid biopsy molecules

细胞外囊泡(EV)分布广泛,全面参与调控细胞生理的各项功能,作为分子生物标志物的活性载体和细胞间通讯的介质,参与肿瘤的发生、发展、转移、耐药等各个环节。EV可以从多种体液中获得,并且与组织具有高度同源性,在维持细胞稳态、细胞间物质交换和信息交流中起重要作用,已成为肿瘤诊断和治疗的理想生物标志物。在新兴的液体活检应用中,EV DNA可作为多种肿瘤的诊断和预后评估分子标志物,在肿瘤诊疗领域是极具潜力的液体活检分子指标。

Extracellular vesicle(EV)is widely distributed and fully involved in the regulation of various aspects of cellular physiology.As active carriers of molecular biomarkers and mediators of intercellular communication,EV is involved in the occurrence,development,metastasis,drug resistance and other links of tumors.The EV,which can be obtained from a variety of body fluids and are highly homologous to tissues,plays an important role in the maintenance of cell homeostasis and the exchange of substances and information between cells,thus becoming an ideal biomarker for tumor diagnosis and treatment.In the emerging liquid biopsy application,EV DNA can be used as a molecular marker for the diagnosis and prognosis evaluation of many kinds of tumors,and it is the most potential molecular marker of liquid biopsy in the field of tumor diagnosis and treatment.