局部晚期可手术食管癌经新辅助放化疗达临床完全缓解后的处理策略

Management strategies for locally advanced operable esophageal carcinoma achieving clinical complete response after neoadjuvant chemoradiotherapy

局部晚期可手术食管癌的标准治疗模式是新辅助放化疗+根治性食管切除术,但鉴于器官保留的临床需求,经新辅助放化疗达临床完全缓解后的处理策略包括等待观察(免手术)、延迟性或挽救性手术、加强系统治疗等,这些处理策略在保证患者局部控制和长期生存的基础上,可显著改善其生命质量。深入探讨这些处理策略的可行性、临床价值,期望为这部分患者提供新的治疗思路。

The standard treatment mode for locally advanced operable esophageal carcinoma is neoadjuvant chemoradiotherapy combined with radical esophagectomy.However,considering the clinical need for organ retention,the treatment strategies for those achieving complete clinical response after neoadjuvant chemoradiotherapy include watchful waiting(omitting surgery),delayed or salvage surgery,and strengthened systemic treatment.These treatment strategies can significantly improve the quality of patients'life while ensuring local control and long-term survival.The feasibility and clinical value of these treatment strategies are deeply explored,hoping to provide new treatment ideas for this group of patients.