慢性创伤性脑病的研究新进展

New advances in the study of chronic traumatic encephalopathy

慢性创伤性脑病(CTE)是一种经历反复颅脑损伤后导致的神经退行性变,以脑内Tau蛋白过度磷酸化异常积累为典型病理特征,由其引发的行为改变和认知障碍给患者的日常生活带来严重影响。目前对于CTE的病理学改变和临床表现展开了一系列研究,初步揭示了CTE的主要特征,并为临床诊断和治疗提供了许多有价值的线索。本文围绕CTE的发展历程、流行病学特征、病理学改变、临床诊断和治疗等方面的最新研究进展进行综述,旨在为CTE的深入研究和临床诊疗提供理论依据和新思路。

Chronic traumatic encephalopathy(CTE)is a kind of neurodegeneration caused by repeated cranio-cerebral injury,which is typically characterized by abnormal accumulation of Tau protein hyperphosphorylation in the brain.A series of studies have been conducted on the pathological changes and clinical manifestations of CTE,which have initially revealed the main features of CTE and provided many valuable clues for clinical diagnosis and treatment.This paper reviews the latest research progress in the development,epidemiological characteristics,pathological changes,clinical diagnosis and treatment of CTE,aiming to provide theoretical basis and new ideas for the in-depth research and clinical diagnosis and treatment of CTE.