桂枝茯苓汤加减联合针刺治疗老年中风恢复期临床研究

Clinical Study on Modified Guizhi Fuling Decoction Combined with Acupuncture for Senile Patients in Stroke Recovery Period

目的:观察桂枝茯苓汤加减联合针刺治疗老年中风恢复期患者的临床疗效。方法:将60例老年中风恢复期患者以随机数字表法分为观察组与对照组各30例。2组均给予常规基础治疗,观察组给予桂枝茯苓汤加减联合针刺治疗,对照组仅给予针刺治疗。比较2组临床疗效,并比较2组神经功能缺损程度、认知功能、肢体运动功能、颅内血流动力学及炎症因子水平。结果:治疗后观察组总有效率93.33%,高于对照组73.33%(P<0.05)。治疗后,2组美国国立卫生研究院卒中量表(NIHSS)评分均降低(P<0.05),且观察组低于对照组(P<0.05),2组简易智能精神状态检查量表(MMSE)、Fugl-Meyer评定量表(FMA)评分均升高(P<0.05),且观察组高于对照组(P<0.05)。治疗后,2组颅内基底动脉(VBA)、大脑前动脉(ACA)、大脑中动脉(MCA)、大脑后动脉(PCA)血流速度均增大(P<0.05),且观察组大于对照组(P<0.05)。治疗后,2组血清肿瘤坏死因子-α (TNF-α)、白细胞介素-6 (IL-6)水平均降低(P<0.05),且观察组低于对照组(P<0.05),2组血清白细胞介素-10 (IL-10)水平均升高(P<0.05),且观察组高于对照组(P<0.05)。结论:针对老年中风患者采取桂枝茯苓汤加减联合针刺治疗可提高临床效果,对患者神经功能、认知功能、肢体运动功能有积极改善效果,并能提高患者颅内血流速度,减轻机体炎症反应。

Objective:To observe the clinical effect of modified Guizhi Fuling Decoction combined with acupuncture on senile patients in stroke recovery period.Methods:A total of 60 cases of senile patients in stroke recovery period were divided into the observation group and the control group according to the random number table method,with 30 cases in each group.Both groups were given routine basic treatment;the observation group was treated with modified Guizhi Fuling Decoction combined with acupuncture,and the control group was simply treated with acupuncture.The clinical effects were compared between the two groups;the scores of degree of neurological impairment,cognitive function and limb motor function were compared between the two groups;the levels of intracranial hemodynamics and inflammatory factors were compared between the two groups.Results:After treatment,the total effective rate was 93.33%in the observation group,higher than that of 73.33%in the control group(P<O.05).After treatment,National Institutes of Health Stroke Scale(NIHsS)scores in the two groups were decreased(P<0.05),and the score in the observation group was lower than that in the control group(P<0.05),the scores of Mini-mental State Examination(MMSE)and Fugl-Meyer Assessment(FMA)in the two groups were increased(P<0.05),and the scores in the observation group were higher than those in the control group(P<0.05).After treatment,the blood flow velocity of intracranial basilar artery(VBA),anterior cerebral artery(ACA),middle cerebral artery(MCA)and posterior cerebral artery(PCA)in the two groups were increased(P<0.05),and the blood flow velocity in the observation group was higher than that in the control group(P<O.05).After treatment,the levels of tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)in serum in the two groups were decreased(P<0.05),and the levels of serum interleukin-10(IL-10)in the two groups were increased(P<0.05),and the level in the observation group Was higher than that in the control group(P<0.05).Conclusion:The application of modified Guizhi Fuling Decoction combined with acupuncture for senile patients with stroke can enhance the clinical effect,improve the neurological function,cognitive function and limb motor function,increase the intracranial blood flow velocity,and reduce the body inflammation.