针刺八脉交会穴联合喹硫平治疗精神分裂症疗效观察及对氧化应激因子、血脂代谢的影响

Observation on Curative Effect of Acupuncture at Eight Confluence Points Combined with Quetiapine for Schizophrenia and Its Effect on Oxidative Stress Factors and Lipid Metabolism

目的:观察针刺八脉交会穴联合喹硫平治疗精神分裂症的疗效及对氧化应激因子、血脂代谢的影响。方法:选取80例精神分裂症患者,按随机数字表法分为对照组及观察组各40例。对照组给予喹硫平治疗,观察组给予针刺八脉交会穴联合喹硫平治疗。比较2组治疗前后阳性与阴性症状量表(PANSS)、临床疗效总评量表(CGI)、氧化应激因子[超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、一氧化氮(NO)、过氧化脂质(LPO)、谷胱甘肽(GSH)]、血脂代谢[血清三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)]水平的变化,比较2组不良反应发生率。结果:治疗后,2组PANSS评分均较治疗前下降(P<0.05),观察组PANSS评分低于对照组(P<0.05)。治疗后,2组CGI评分均较治疗前下降(P<0.05),观察组CGI评分低于对照组(P<0.05)。治疗后,2组SOD、GSH-Px、GSH水平均较治疗前上升(P<0.05),NO、LPO水平均较治疗前下降(P<0.05);观察组SOD、GSH-Px、GSH水平均高于对照组(P<0.05),NO、LPO水平均低于对照组(P<0.05)。治疗后,2组TG、TC、LDL-C水平均较治疗前上升(P<0.05),HDL-C水平均较治疗前下降(P<0.05);观察组TG、TC、LDL-C水平均低于对照组(P<0.05),HDL-C水平高于对照组(P<0.05)。对照组不良反应发生率为27.5%,观察组为5.0%,2组比较,差异有统计学意义(P<0.05)。结论:针刺八脉交会穴联合喹硫平治疗精神分裂症临床疗效显著,能有效改善氧化应激反应,调节血脂代谢水平,安全性高。

Objective:To observe the curative effect of acupuncture at eight confluence points combined with Quetiapine for schizophrenia and its effect on oxidative stress factors and lipid metabolism.Methods:A total of 80 cases of patients with schizophrenia were selected as the research subjects and divided into the control group and the observation group according to the random number table method,With 40 cases in each group.The control group was treated with Quetiapine,and the observation group Was treated with Quetiapine combined with acupuncture at eight confluence points.The changes in Positive and Negative Syndrome Scale(PANSS),Clinical Global Impression(CGl),oxidative stress factors[superoxide dismutase(SOD),glutathione peroxidase(GSH-Px),nitric oxide(NO),lipid peroxidation(LPO),and glutathione(GSH)],and levels of blood lipid metabolism[triglycerides(TG),total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C),and low-density lipoprotein cholesterol(LDL-C)]were compared before and after treatment in two groups.The incidence of adverse reactions was compared between the two groups.Results:After treatment,the PANSS scores in the two groups were decreased when compared with those before treatment(P<0.05),and the PANSS score in the observation group was lower than that in the control group(P<0.05).After treatment,the CGl scores in the two groups were decreased when compared with those before treatment(P<0.05),and the CGl score in the observation group was lower than that in the control group(P<0.05).After treatment,the levels of SOD,GSH Px,and GSH in the two groups were increased when compared with those before treatment(P<0.05),and the levels of NO and LPO were decreased when compared with those before treatment(P<0.05);the levels of SOD,GSH Px,and GSH in the observation group Were higher than those in the control group(P<0.05),and the levels of NO and LPO were lower than those in the control group(P<0.05).After treatment,the levels of TG,TC,and LDL-C in the two groups were increased when compared with those before treatment(P<0.05),and the levels of HDL-C were decreased when compared with those before treatment(P<0.05);the levels of TG,TC,and LDL-C in the observation group were lower than those in the control group(P<0.05),and the level of HDL-C was higher than that in the control group(P<0.05).The incidence of adverse reactions was 27.5%in the control group,and 5.0%in the observation group,the difference being significant(P<0.05).Conclusion:Acupuncture at eight confluence points combined with quetiapine has a significant clinical effect in treating schizophrenia,which can effectively improve oxidative stress responses,and regulate blood lipid metabolism with high safety.