矽肺合并系统性硬化症诊治研究进展

Progress in diagnosis and treatment of silicosis complicated with systemic sclerosis

矽肺是职业病中难治愈、预后差、病死率较高的一种职业病。系统性硬化症是一种慢性自身免疫性疾病,其特征是自身抗体产生、小血管病变和纤维母细胞功能障碍,导致细胞外基质不受控制的沉积。矽肺合并系统性硬化症临床称为伊拉斯谟(Erasmus)综合征,其发病机制仍未阐明,目前尚无形成统一诊疗规范,文章对近年来矽肺合并系统性硬化症的国际国内相关研究进行综述,为矽肺合并系统性硬化症的诊疗提供借鉴。

Silicosis is a kind of occupational disease which is difficult to cure,has poor prognosis and high fatality rate.Systemic sclerosis is a chronic autoimmune disease characterized by autoantibody production,small vessel lesions,and fibroblast dysfunction,leading to uncontrolled deposition of extracellular matrix.Silicosis complicated with systemic sclerosis is clinically known as Erasmus syndrome,the pathogenesis of which has not yet been clarified,and no unified diagnosis and treatment norms have been formed.This article reviews relevant international and domestic studies on silicosis complicated with systemic sclerosis in recent years,providing reference for the diagnosis and treatment of silicosis complicated with systemic sclerosis.