CT引导下经皮穿刺冷冻消融治疗肺转移癌

CT-guided percutaneous cryoablation for treating lung metastases

目的观察CT引导下经皮穿刺冷冻消融治疗肺转移癌的有效性及安全性。方法对59例肺转移癌患者(80个转移灶)行CT引导下经皮穿刺氩氦刀冷冻消融治疗,统计治疗有效率、疾病控制率、并发症及生存情况[局部肿瘤进展(LTP)时间、无进展生存期(PFS)及总生存期(OS)]。结果共对59例80个肺转移癌成功完成75例次冷冻消融。冷冻消融治疗有效率为85.33%(64/75),疾病控制率为94.67%(71/75),治疗后1及2年的LTP率分别为49.08%及32.83%、无进展生存率分别为37.02%及19.37%、总生存率分别为58.14%及33.49%。72例次(72/75,96.00%)出现国际介入放射学学会(SIR)A~B级并发症,3例次(3/75,4.00%)出现SIR C级并发症,其中咳嗽(49/75,65.33%)、咯血(41/75,54.67%)及疼痛(19/75,25.33%)最为常见;未见SIR D~F级并发症。结论CT引导下经皮穿刺氩氦刀冷冻消融治疗肺转移癌较为有效且安全。

Objective To observe the efficacy and safety of CT-guided percutaneous cryoablation for treating lung metastases.Methods Data of 80 lung metastases in 59 patients who underwent CT-guided percutaneous argon-helium cryoablation were retrospectively analyzed.The effective rate of treatment,disease control rate,complications and survival(local tumor progression[LTP]time,progression free survival[PFS],overall survival[OS])were observed.Results Totally 75 times of cryoablation were successfully performed on 80 lung metastases in 59 patients.The effective rate of treatment was 85.33%(64/75),and the disease control rate was 94.67%(71/75).One and 2 years after cryoablation,the LTP rate was 49.08% and 32.83%,progression free survival rate was 37.02% and 19.37%,and overall survival rate was 58.14% and 33.49%,respectively.Society of Interventional Radiology(SIR)grade A—B complications were occurred in 72 times(72/75,96.00%),while SIR grade C complications were observed in 3 times(3/75,4.00%).Cough(49/75,65.33%),hemoptysis(41/75,54.67%)and pain(19/75,25.33%)were the most common complications after cryoablation.No SIR grade D—F complication occurred.Conclusion CT-guided percutaneous cryoablation was effective and safety for treating lung metastases.