对比冷冻消融与微波消融治疗兔VX2椎旁肿瘤的有效性及安全性

Comparison on efficacy and safety of cryoablation and microwave ablation for treating rabbit VX2 paravertebral tumors

目的对比冷冻消融(CA)与微波消融(MWA)治疗兔VX2椎旁肿瘤的有效性及安全性。方法选取48只新西兰大白兔建立VX2椎旁肿瘤模型并随机分为CA组(n=24)及MWA组(n=24),比较组间完全消融率、生存率、布里斯托尔兔疼痛量表(BRPS)评分及并发症发生率。结果CA组完全消融率及治疗后21天生存率分别为91.67%(22/24)及33.33%(8/24),均高于MWA组[66.67%(16/24)及16.67%(4/24)](P均<0.05)。CA组治疗后4 h、1天、4天、7天及14天BRPS评分均低于MWA组(P均<0.001);2组上述时间点BRPS评分均低于治疗前(P均<0.05)。CA组并发症发生率(3/24,12.50%)低于MWA组(8/24,33.33%)(P<0.05)。结论CA治疗兔VX2椎旁肿瘤的安全性及有效性均优于MWA。

Objective To compare the efficacy and safety of cryoablation(CA)and microwave ablation(MWA)for treating rabbit VX2 paravertebral tumors.Methods Forty-eight New Zealand rabbits were selected to establish models of VX2 paravertebral tumor.The rabbits were then randomly divided into CA group(n=24)and MWA group(n=24).The complete ablation rates,survival rates,Bristol rabbit pain scale(BRPS)scores and incidence of complications were compared between groups.Results The complete ablation rate and 21-day survival rate of CA group was 91.67%(22/24)and 33.33%(8/24),both better than those of MWA group(66.67%[16/24]and 16.67%[4/24]),respectively(both P<0.05).BRPS scores of 4 h,1 day,4 days,7 days and 14 days after treatment of CA group were all lower than those of MWA group(all P<0.001),and BRPS scores of both groups at the above time points were all lower than that before treatments(all P<0.05).The incidence of complications in CA group(3/24,12.50%)was lower than in MWA group(8/24,33.33%)(P<0.05).Conclusion The efficacy and safety of CA were both better than those of MWA for treating rabbit VX2 paravertebral tumors.