摘要
目的探讨钆塞酸二钠多期增强MRI扫描所得胆道评分和肝肌比值在评估肝纤维化病理分级中的应用价值。方法回顾性分析2020年1月—2023年5月广西医科大学附属武鸣医院51例慢性乙型肝炎肝纤维化患者的MRI和临床资料。将51例肝纤维化患者分为两组,其中S1、S2期为低级别组(n=30),S3、S4期为高级别组(n=21)。扫描采用GE Architact 3.0T磁共振扫描仪,包括常规肝脏平扫,动脉期、门静脉期、延迟期、肝胆期、排泄期的增强扫描。对不同级别肝纤维化患者进行胆道评分和测量肝肌比值。计量资料组间比较采用成组t检验,计数资料组间比较采用χ2检验或Fisher确切检验法。绘制受试者工作特征曲线(ROC曲线)评价MRI指标对肝纤维化病理分级的诊断价值。结果低级别组胆道评分(3.67±0.55)大于高级别组(2.57±0.75)(t=6.05,P<0.001);低级别组门静脉期、延迟期、肝胆期的肝肌比值(2.38±0.76,2.48±0.70,4.10±0.63)均大于高级别组(1.97±0.18,1.99±0.27,3.16±0.47)(t值分别为2.41、3.09、5.81,P值分别为0.020、0.003、<0.001)。上述指标区分低、高级别肝纤维化的ROC曲线下面积分别为0.86、0.79、0.82、0.88,诊断高级别肝纤维化的敏感度分别为70%、63.3%、83.3%、96.7%,特异度分别为90%、95.2%、74.1%、100%。胆道评分联合肝胆期肝肌比值的ROC曲线下面积达0.95,敏感度85.7%,特异度96.7%。结论MRI钆塞酸二钠多期增强扫描所得胆道评分和肝胆期肝肌比值在区分低、高级别肝纤维化方面具有较高的诊断效能,对临床肝纤维化的诊治有一定的指导价值。
Objective To investigate the value of biliary score and hepatic signal intensity-to-muscle signal intensity ratio(HMR)obtained by multiphase contrast-enhanced MRI scan using Gd-EOB-DTPA in evaluating the pathological grade of liver fibrosis.Methods A retrospective analysis was performed for the MRI and clinical data of 51 patients with chronic hepatitis B liver fibrosis in Wuming Hospital Affiliated to Guangxi Medical University from January 2020 to May 2023.The 51 patients with liver fibrosis were divided into low-grade group(S1-S2)and high-grade group(S3-S4).GE Architact 3.0T MR scanner was used to perform MRI scans,including routine plain scan and contrast-enhanced scan at arterial phase,portal venous phase,delayed phase,hepatobiliary phase,and excretory phase,and biliary score and HMR were measured for the patients with different grades of liver fibrosis.The t-test was used for comparison of continuous data between groups,and the chi-square test or the Fisher’s exact test was used for comparison of categorical data between groups.The receiver operating characteristic(ROC)curve was plotted to evaluate the value of MRI indicators in determining the pathological grade of liver fibrosis.Results Among the 51 patients with liver fibrosis,there were 30 patients in the low-grade group and 21 in the high-grade group.Compared with the high-grade group,the low-grade group had significantly higher biliary score(3.67±0.55 vs 2.57±0.75,t=6.05,P<0.001)and HMR at portal venous phase(2.38±0.76 vs 1.97±0.18,t=2.41,P=0.020),delayed phase(2.48±0.70 vs 1.99±0.27,t=3.09,P=0.003),and hepatobiliary phase(4.10±0.63 vs 3.16±0.47,t=5.81,P<0.001).The above indicators had an area under the ROC curve(AUC)of 0.86,0.79,0.82,and 0.88,respectively,in distinguishing low-and high-grade liver fibrosis,with a positive rate of 70%,63.3%,83.3%,and 96.7%,respectively,and a negative rate of 90%,95.2%,74.1%,and 100%,respectively,in the diagnosis of high-grade liver fibrosis.Biliary score combined HMR had an AUC of 0.95,with a positive rate of 85.7%and a negative rate of 96.7%.Conclusion Biliary score and HMR at hepatobiliary phase obtained by multiphase contrast-enhanced MRI scan using Gd-EOBDTPA has a relatively high diagnostic efficacy in distinguishing between low-and high-grade liver fibrosis and a certain guiding value for the diagnosis and treatment of liver fibrosis in clinical practice.
作者
黄璐
陆力坚
HUANG Lu;LU Lijian(Department of Infectious Diseases,The First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China;Department of Radiology,Wuming Hospital Affiliated to Guangxi Medical University,Nanning 530199,China)
出处
《临床肝胆病杂志》
CAS
北大核心
2024年第4期720-725,共6页
Journal of Clinical Hepatology
基金
广西医疗卫生适宜技术开发与推广应用项目(S2020045)。
关键词
肝纤维化
磁共振成像
钆塞酸二钠
Hepatic Fibrosis
Magnetic Resonance Imaging
Gadolinium Plug Acid Disodium