Hedgehog信号通路在肝细胞癌中的作用及其与肿瘤微环境的关系

Role of the Hedgehog signaling pathway in hepatocellular carcinoma and its tumor microenvironment

Hedgehog(Hh)信号通路在肝细胞癌的发生发展和肿瘤微环境中发挥重要作用。Hh信号异常激活可加速肿瘤的生长。Hh信号通路和肿瘤微环境之间的相互串扰与肿瘤的生长和抑制性肿瘤微环境的形成密切相关。有证据表明,抑制Hh信号在抑制肝细胞癌生长中发挥重要作用。本文就Hh信号异常激活在肝细胞癌和肝癌肿瘤微环境中作用及机制的研究现状与潜在的治疗意义作一综述,为肝癌的治疗提供新的思路。

The Hedgehog(Hh)signaling pathway plays an important role in the development and progression of hepatocellular carcinoma and its tumor microenvironment,and abnormal activation of Hh signal can accelerate the growth of tumor.The crosstalk between the Hh signaling pathway and TME is closely associated with tumor growth and the formation of inhibitory tumor microenvironment.Evidence shows that inhibition of Hh signal plays an important role in inhibiting the growth of hepatocellular carcinoma.This article reviews the current research status of the role,mechanism,and potential therapeutic significance of abnormal activation of Hh signal in hepatocellular carcinoma and its tumor microenvironment,so as to provide new ideas for the treatment of hepatocellular carcinoma.