肝衰竭并发急性胰腺炎的机制及预防

Mechanism and prevention of liver failure complicated by acute pancreatitis

肝衰竭病情进展快,并发症多,病情十分凶险。在肝衰竭发展过程中,并发急性胰腺炎十分常见;而急性胰腺炎的临床症状及体征与肝衰竭并发自发性腹膜炎极其相似,易被忽略。本文通过炎症反应、十二指肠乳头功能障碍、肠道菌群失调、氧化应激、微循环障碍等5个方面对肝衰竭并发急性胰腺炎的机制进行阐述,并根据其作用机制提出相应预防手段。

Liver failure often has rapid progression,multiple complications,and dangerous conditions.Acute pancreatitis is a common comorbidity during the progression of liver failure,and since acute pancreatitis has extremely similar clinical symptoms and signs to liver failure complicated by spontaneous peritonitis,it is often neglected in clinical practice.This article elaborates on the mechanisms of liver failure complicated by acute pancreatitis from the five aspects of inflammatory response,duodenal papillary dysfunction,gut microbiota dysbiosis,oxidative stress,and microcirculatory disturbance and proposes corresponding preventive measures based on these mechanisms.