蛋白质精氨酸甲基转移酶调控骨形成与骨愈合的研究进展

Research progress of protein arginine methyltransferase regulating bone formation and bone healing

蛋白质精氨酸甲基化是由蛋白质精氨酸甲基转移酶(PRMTs)介导的调控蛋白质功能的重要翻译后修饰(PTM),其与众多疾病的发生发展密切相关。精氨酸的甲基化修饰与炎症相关疾病及骨折愈合关系密切,PRMTs表达下降可导致骨折延迟愈合甚至不愈合。PRMT5、PRMT6在骨折愈合方面均有重要意义,其与PI3K-AKT通路、NF-κB通路息息相关。探讨蛋白质精氨酸甲基化与骨折愈合之间的联系,可为预防骨折延迟愈合甚至不愈合提供新思路。

Protein arginine methylation is an important post-translational modification(PTM)mediated by protein arginine methyltransferase(PRMTs),which is closely related to the occurrence and development of many diseases.Methylation of arginine is closely related to inflammatory diseases and fracture healing.Decreased expression of PRMTs can lead to delayed or even non-healing of fractures.Both PRMT5 and PRMT6 play an important role in fracture healing and are closely related to the PI3K-AKT and NF-κB pathways.Exploration the relationship between protein arginine methylation and fracture healing can provide a new way to prevent delayed or even non-healing fracture.