血浆BNP、hsCRP水平与急性冠状动脉综合征患者GRACE评分的关系

Correlations of levels of plasma BNP and hsCRP with GRACE scores in patients with acute coronary syndrome

目的分析血浆B型钠尿肽(BNP)、超敏C反应蛋白(hsCRP)水平与急性冠状动脉综合征(ACS)患者急性冠状动脉事件注册系统(GRACE)评分的关系。方法观察性研究。抽取2019年1月至2021年12月安阳市人民医院收治的ACS患者112例为观察组,观察组按照GRACE评分细分为低危组(41例)、中危组(38例)、高危组(33例),另抽取同期健康体检者112例为健康组。检测并比较各组血浆BNP、hsCRP水平及GRACE评分,分析不同GRACE评分的ACS患者病变血管状况,分析血浆BNP、hsCRP水平与ACS患者GRACE评分的相关性。结果观察组BNP、hsCRP水平及GRACE评分高于健康组,差异有统计学意义(P<0.05)。中危组和高危组BNP、hsCRP水平高于低危组(P<0.05)。低危组双支血管病变者比例与中危组、高危组比较,差异未见统计学意义(P>0.05);低危组单支血管病变者比例(51.22%,21/41)高于中危组(21.05%,8/38)、高危组(3.03%,1/33),且三支血管病变者比例(14.63%,6/41)低于中危组(42.11%,16/38)、高危组(54.55%,18/33),差异有统计学意义(P<0.05)。Pearson结果显示,血浆BNP、hsCRP水平与ACS患者GRACE评分呈正相关(r=0.51、0.63,P均<0.05)。结论血浆BNP、hsCRP水平可随着ACS患者病情加重而逐渐升高,且BNP、hsCRP水平与GRACE评分呈正相关。

Objective To analyze the correlations of levels of plasma B-type natriuretic peptide(BNP)and hypersensitive C-reactive protein(hsCRP)with global registry of acute coronary events(GRACE)score in patients with acute coronary syndrome(ACS).Methods A total of 112 ACS patients admitted to Anyang People’s Hospital from January 2019 to December 2021 were enrolled in the observational study as the observation group,and the observation group was subdivided into low-risk group(41 cases),intermediate-risk group(38 cases)and high-risk group(33 cases)according to the GRACE score.Moreover,112 individuals who underwent physical examination during the same period were selected as the healthy group.The levels of plasma BNP,hsCRP and GRACE scores in each group were detected and compared.The diseased vascular status of ACS patients with different GRACE scores were analyzed.And the correlations of the levels of plasma BNP and hsCRP with GRACE scores in ACS patients were analyzed.Results The level of BNP,level of hsCRP and GRACE score in the observation group were higher than those in the healthy group(P<0.05).The levels of BNP and hsCRP in the intermediate-risk group and the high-risk group were higher than those in the low-risk group(P<0.05).The proportion of patients with double-vessel disease in the low-risk group did not significantly differ from that in the intermediate-risk group and the high-risk group(P>0.05).The proportion of patients with single-vessel disease in the low-risk group(51.22%,21/41)was higher than that in the intermediate-risk group(21.05%,8/38)and the high-risk group(3.03%,1/33),P<0.05.The proportion of patients with three-vessel disease in the low-risk group(14.63%,6/41)was lower than that in the intermediate-risk group(42.11%,16/38)and the high-risk group(54.55%,18/33),P<0.05.The results of Pearson analysis showed that the levels of plasma BNP and hsCRP were positively correlated with the GRACE score in ACS patients(r=0.51,0.63;all P<0.05).Conclusions The levels of plasma BNP and hsCRP gradually increase with the aggravation of ACS,and the levels of BNP and hsCRP are positively correlated with GRACE score.