唑来膦酸联合依降钙素在骨质疏松性骨折术后患者中的应用效果

Application of zoledronic acid combined with elcatonin after surgery for osteoporotic fractures

目的探讨唑来膦酸联合依降钙素在骨质疏松性骨折术后患者中的应用效果。方法随机对照研究。抽取2017年1月至2021年12月河南省中医院收治的骨质疏松性骨折术后患者74例,按照随机数字表法分为对照组和观察组,每组37例。对照组采用唑来膦酸治疗,观察组在对照组基础上采用依降钙素治疗。比较两组治疗效果,比较两组治疗前后骨密度、骨折愈合指标[碱性磷酸酶(ALP)、骨钙素(BGP)、胰岛素样生长因子(IGF)]、视觉模拟评分法(VAS)评分、Oswestry功能障碍指数(ODI),比较两组不良反应发生率。结果观察组总有效率(97.30%,36/37)高于对照组(78.38%,29/37),P<0.05。治疗后,观察组腰椎、股骨颈骨密度高于对照组(P<0.05);治疗后,观察组ALP、BGP、IGF水平高于对照组(P<0.05);治疗后,观察组VAS评分、ODI低于对照组(P<0.05)。观察组不良反应发生率(10.81%,4/37)与对照组(5.41%了,2/37)比较差异未见统计学意义(P>0.05)。结论唑来膦酸联合依降钙素应用于骨质疏松性骨折术后患者的效果显著,能改善腰椎和股骨颈骨密度,促进骨折愈合,缓解疼痛症状,改善患者功能障碍,且无明显不良反应。

Objective To investigate the application effect of zoledronic acid combined with elcatonin after surgery for osteoporotic fractures.Methods The randomized controlled study was conducted on 74 patients who had experienced surgery for osteoporosis fractures in Henan Traditional Chinese Medicine Hospital from January 2017 to December 2021.They were divided into control group and observation group by random number table method,with 37 cases in each group.The control group was treated with zoledronic acid,while the observation group was treated with elcatonin based on the treatment of the control group.The efficacy of the two groups were compared.The bone density,fracture healing indicators,including alkaline phosphatase(ALP),osteocalcin(BGP),insulin like growth factor(IGF),visual analogue scale(VAS)scores,and Oswestry dysfunction index(ODI)were compared between the two groups before and after treatment.And the incidence of adverse reactions were compared between the two groups.Results The total effective rate in the observation group(97.30%,36/37)was higher than that in the control group(78.38%,29/37),P<0.05.After treatment,the bone density of the lumbar spine and femoral neck in the observation group were higher than those in the control group(P<0.05).After treatment,the levels of ALP,BGP and IGF in the observation group were higher than those in the control group(P<0.05).After treatment,the VAS score and ODI in the observation group were lower than those in the control group(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the observation group(10.81%,4/37)and the control group(5.41%,2/37),P>0.05.Conclusions The combination of zoledronic acid with elcatonin has a significant effect on patients after surgery for osteoporosis fractures.It can improve the bone density of the lumbar spine and femoral neck,promote fracture healing,alleviate pain symptoms,and improve function disorder,without significant adverse reactions.