复方丹参滴丸在急性心肌梗死经皮冠状动脉介入术后辅助治疗中的应用价值

Application value of compound Danshen dropping pills in the adjuvant treatment of acute myocardial infarction after percutaneous coronary intervention

目的分析复方丹参滴丸在急性心肌梗死经皮冠状动脉介入术(PCI)后辅助治疗中的应用价值。方法随机对照研究。抽取2021年2月至2023年2月安阳市中医院收治的150例行PCI治疗的急性心肌梗死患者,按随机数字表法分为中医组与西医组,每组75例。西医组术后给予常规治疗,中医组在西医组基础上给予复方丹参滴丸。比较两组临床效果、心功能[心脏指数(CI)、心脏每搏量(SV)、左室射血分数(LVEF)]、心肌损伤标志物[心肌肌钙蛋白T(cTnT)、心肌钙调蛋白依赖性蛋白激酶Ⅱ(CaMKⅡ)]水平、血液流变学指标[红细胞沉降率(ESR)、纤维蛋白原(FIB)、血浆黏度(PV)]及不良心血管事件发生率。结果中医组总有效率(97.33%,73/75)高于西医组(85.33%,64/75),P<0.05。治疗后,中医组CI、SV、LVEF水平高于西医组(P<0.05),cTnT、CaMKⅡ水平低于西医组(P<0.05)。治疗后,中医组ESR、FIB、PV低于西医组(P<0.05)。中医组不良心血管事件发生率(4.00%,3/75)低于西医组(14.67%,11/75),P<0.05。结论复方丹参滴丸应用于急性心肌梗死患者PCI术后,可减轻患者的心肌损伤,改善血液流变学指标,提高心功能,并可降低不良心血管事件发生率。

Objective To analyze the application value of compound Danshen dropping pills in the adjuvant treatment of acute myocardial infarction after percutaneous coronary intervention(PCI).Methods This was a randomized controlled study.A total of 150 patients with acute myocardial infarction treated by PCI in Anyang Traditional Chinese Medicine Hospital from February 2021 to February 2023 were selected,and they were divided into traditional Chinese medicine group and western medicine group by random number table method,with 75 cases in each group.The western medicine group was treated by routine treatment after operation,and the traditional Chinese medicine group was treated with compound Danshen dropping pills based on the treatment of the western medicine group.The clinical effects,cardiac function assessed by cardiac index(CI),cardiac stroke volume(SV)and left ventricular ejection fraction(LVEF),levels of myocardial injury markers,including cardiac troponin T(cTnT)and cardiac calmodulin dependent protein kinaseⅡ(CaMKⅡ),hemorheologic indexes,including erythrocyte sedimentation rate(ESR),fibrinogen(FIB)and plasma viscosity(PV),and incidence of adverse cardiovascular events were compared between the two groups.Results The total effective rate of the traditional Chinese medicine group was 97.33%(73/75),which was higher than the 85.33%(64/75)of the western medicine group(P<0.05).After treatment,the traditional Chinese medicine group had higher CI,SV and LVEF,and it had lower levels of cTnT and CaMKⅡ,compared with the western medicine group(P<0.05).After treatment,ESR,FIB and PV in the traditional Chinese medicine group were lower than those in the western medicine group(P<0.05).The incidence of adverse cardiovascular events in the traditional Chinese medicine group(4.00%,3/75)was lower than that in the western medicine group(14.67%,11/75),P<0.05.Conclusions Compound Danshen dropping pills used in patients with acute myocardial infarction after PCI can reduce myocardial injury,improve hemorheology and cardiac function,and reduce the incidence of adverse cardiovascular events.