益气维血胶囊联合多糖铁复合物对妊娠期轻中度缺铁性贫血患者铁代谢的影响

Effect of Yiqi Weixue capsule combined with polysaccharide iron complex on iron metabolism in patients with mild to moderate iron-deficiency anemia during pregnancy

目的研究益气维血胶囊联合多糖铁复合物对妊娠期轻中度缺铁性贫血(IDA)患者铁代谢的影响。方法回顾性观察性研究。抽取2018年9月至2023年5月河南中医药大学第一附属医院收治的妊娠期轻中度IDA患者94例,按照治疗方法分为单一组和联合组,每组47例。单一组采用多糖铁复合物治疗,联合组在单一组基础上联用益气维血胶囊。比较两组疗效,比较两组治疗前后血常规指标[血红蛋白(Hb)、红细胞计数(RBC)、平均红细胞体积(MCV)]水平、铁代谢指标[铁蛋白(SF)、血清铁(SI)]水平,比较两组不良妊娠结局发生率及不良反应发生率。结果联合组总有效率(95.74%,45/47)高于单一组(78.72%,37/47),P<0.05。治疗后,联合组Hb、RBC、MCV水平高于单一组(P<0.05);治疗后,联合组SF、SI水平高于单一组(P<0.05)。联合组不良妊娠结局发生率(4.26%,2/47)与单一组(8.51%,4/47)比较差异未见统计学意义(P>0.05);联合组不良反应发生率(4.26%,2/47)低于单一组(21.28%,10/47),P<0.05。结论益气维血胶囊联合多糖铁复合物治疗妊娠期轻中度IDA效果显著,能改善患者血常规指标和铁代谢指标,降低不良反应发生率。

Objective To study the effect of Yiqi Weixue capsule combined with polysaccharide iron complex on iron metabolism in patients with mild to moderate iron-deficiency anemia(IDA)during pregnancy.Methods This study was a retrospective observational study.A total of 94 patients with mild to moderate IDA during pregnancy treated in the First Affiliated Hospital of Henan University of Chinese Medicine from September 2018 to May 2023 were selected,and they were divided into single group and combined group according to therapeutic method,with 47 cases in each group.The single group was treated with polysaccharide iron complex,and the combined group was treated with Yiqi Weixue capsule based on the treatment of the single group.The efficacy,levels of blood routine indexes,including hemoglobin(Hb),red blood cell count(RBC)and mean corpuscular volume(MCV),levels of iron metabolism indexes,including serum ferritin(SF)and serum iron(SI),were compared between the two groups before and after treatment.The incidence of adverse pregnancy outcome and incidence of adverse reactions of the two groups were compared.Results The total effective rate of the combined group(95.74%,45/47)was higher than that of the single group(78.72%,37/47),P<0.05.After treatment,the combined group had higher levels of Hb,RBC and MCV compared with the single group(P<0.05).After treatment,the combined group had higher levels of SF and SI compared with the single group(P<0.05).There was no significant difference in the incidence of adverse pregnancy outcomes between the combined group(4.26%,2/47)and the single group(8.51%,4/47),P>0.05.The incidence of adverse reactions in the combined group(4.26%,2/47)was lower than that in the single group(21.28%,10/47),P<0.05.Conclusions The combination of Yiqi Weixue capsule and polysaccharide iron complex has a significant effect in the treatment of mild to moderate IDA,which can improve blood routine and iron metabolism indicators,and reduce incidence of adverse reactions.