白虎加人参汤的古代文献考证及现代临床应用

Ancient Literature Research and Modern Clinical Application of White Tiger Decoction Plus Ginseng

目的:对古代文献中白虎加人参汤的历史沿革、药量、药物基原与炮制方法、制法与煎服法及主治病证等进行考证,并总结白虎加人参汤的现代临床主治疾病。方法:检索第五版中华医典数据库、中医智库、湖南中医药大学读秀数据库等中医古籍数据库,以“白虎加人参汤”“白虎加参汤”“人参白虎汤”“化斑汤”为关键词,总结古代文献中有关白虎加人参汤的药物组成、用量、炮制方法、制法、煎服法及主治病证等。再以中国知网数据库为基础,以“白虎加人参汤”为主题词进行检索,统计白虎加人参汤现代临床应用病证。结果:共收集到442条有关白虎加人参汤记载的文献数据,涉及167部医书,筛选出明确记载白虎加人参汤药物组成、用量、炮制方法、制法、煎服法等详细内容的古籍共84部。可得到白虎加人参汤药物组成及用量为盐知母82.8 g,生石膏(打碎)220.8 g,炒甘草27.6 g,人参27.6 g或41.4 g,粳米110 g;煎服方法为加水2 000 mL,先煮石膏20~30 min,再加入余下药物,煮至粳米熟,总共煎取药液600 mL,过滤去滓,将600 mL药液分3次温服,其中人参可另煎后将参汁兑服;主治病症为中暍(中暑)、膈消、消渴等。白虎加人参汤在现代临床应用中可用于治疗多系统疾病,其中以内分泌系统的糖尿病居多。结论:通过对白虎加人参汤的古代文献及现代临床应用文献进行考证挖掘,可为白虎加人参汤的现代临床应用提供一定的参考依据。

Objective:To investigate the history,dosage,drug base,processing method,decocting method and symptoms of White Tiger Decoction Plus Ginseng in ancient literature,and to summarize its modern application.Methods:The database of the 5th edition of Chinese Medical Code,Chinese Medicine Think Tank,Duxiu Database of Hunan University of Chinese Medicine and other ancient Chinese medicine books were searched.With"Baihu plus Renshen Tang","Baihu plus Shen Tang","Renshen Baihu Tang"and"Huaban Tang"as key words,the drug composition,dosage,processing method,preparation method,decocting method and symptoms of White Tiger Decoction Plus Ginseng in ancient literature were summarized.Then,based on the database of China National Knowledge Network,with"Baihu plus Renshen Tang"as the main title,the search was carried out to calculate the modern clinical application of White Tiger Decoction Plus Ginseng.Results:A total of 442 literature on White Tiger Decoction Plus Ginseng were collected,involving 167 medical books,and 84 ancient books were selected,which clearly recorded the composition,dosage,processing method,preparation method and decocting method of White Tiger Decoction Plus Ginseng.The drug composition and dosage of White Tiger Decoction plus Ginseng were as follows:salted Zhimu(Rhizoma Anemarrhenae)82.8 g,raw Shigao(Gypsum Fibrosum)220.8 g,fried Gancao(Radix Glycyrrhizae)27.6 g,Renshen(Radix Ginseng)27.6 g/41.4 g,Jingmi(Semen Oryza Sativa)110 g;The decocting method was to add 2000 mL of water,boil Shigao for 20 to 30 minutes,then add the remaining drugs,boil Jingmi until fully cooked,decocting about 600 mL of the liquid in total,filtering the dregs,taking 600 mL of the liquid warm for three times,in which Renshen can be decocted separately and then mixed with ginseng juice.The main symptoms are heatstroke,diabetes involving the diaphragm and waisting thirst.In modern clinical application,White Tiger Decoction Plus Ginseng can be used to treat multi-system diseases,among which diabetes of endocrine system is the majority.Conclusion:Through textual research on ancient literature and modern clinical application literature,White Tiger Decoction Plus Ginseng can provide certain reference for its modern clinical application.