连朴泻心汤治疗脾胃湿热型慢性萎缩性胃炎临床研究

Clinical Study on Coptis and Officinal Magnolia Bark Heart-Draining Decoction in the Treatment of Chronic Atrophic Gastritis with Syndrome of Dampness-Heat of Spleen and Stomach

目的:观察自拟连朴泻心汤治疗脾胃湿热型慢性萎缩性胃炎的临床疗效。方法:将74例慢性萎缩性胃炎患者按照随机数字表法分为对照组和观察组,每组各37例。对照组予西医常规治疗,观察组在对照组治疗的基础上口服自拟连朴泻心汤。比较两组患者胃镜疗效、幽门螺杆菌(helicobacter pylori, Hp)清除率及治疗前后临床症状评分、临床症状分级情况。结果:对照组有效率为81.08%,观察组有效率为94.59%,两组患者有效率比较,差异具有统计学意义(P<0.05)。两组患者治疗后临床症状积分低于本组治疗前,且观察组低于同期对照组(P<0.05)。对照组Hp阳性12例,转阴3例,清除率为25%;观察组Hp阳性12例,转阴6例,清除率为40%,两组患者Hp清除率比较,差异具有统计学意义(P<0.05)。两组患者治疗后轻度患者例数多于本组治疗前,重度患者少于本组治疗前,且治疗后组间比较,差异具有统计学意义(P<0.05)。结论:自拟连朴泻心汤治疗脾胃湿热型慢性萎缩性胃炎临床疗效确切,可缓解患者胸脘部胀满、胃脘部热痛、口苦、口黏、头身重着、纳呆嘈杂等不适症状,并能修复损伤的胃黏膜。

Objective:To observe the clinical efficacy of self-made Coptis and Officinal Magnolia Bark Heart-Draining Decoction on chro-nic atrophic gastritis with syndrome of dampness-heat of spleen and stomach.Methods:A total of 74 patients with chronic atrophic gastri-tis were divided into the control group and the observation group according to the random number table method,with 37 cases in each group.The control group was given conventional treatment of Western medicine,while the observation group was given self-made Coptis and Officinal Magnolia Bark Heart-Draining Decoction on the basis of the control group.The efficacy of gastroscopy,the clearance rate of helicobacter pylori(Hp),the clinical symptom scores and clinical symptom classification before and after treatment were compared be-tween the two groups.Results:The effective rate of the control group was 81.08%,while that of the observation group was 94.59%,and the difference was statistically significant(P<0.05).The clinical symptom scores of the two groups after treatment were lower than those before treatment,and the observation group's above scores were lower than those of the control group during the same period(P<0.05).In the control group,12 cases were Hp positive,3 cases were negative,and the clearance rate was 25%;in the observation group,12 cases were Hp positive,6 cases were negative,and the clearance rate was 40%,and the diference was statistically significant(P<0.05).After treatment,the number of mild patients in the two groups was more than that before treatment,while the number of se-vere patients was less than that before treatment,and all the differences was statistically significant(P<0.05).Conclusion:Self-made Coptis and Officinal Magnolia Bark Heart-Draining Decoction has definite clinical efficacy on chronic atrophic gastritis with syndrome of dampness-heat of spleen and stomach,can relieve the discomfort symptoms such as chest distention,stomach heat and pain,bitter mouth,sticky mouth,heavy head and body,and poor appetite,etc.and repair the damaged gastric mucosa.