带状疱疹合并恶性肿瘤患者的临床特征及影响因素分析

An analysis of clinical characteristics and influencing factors in patients with herpes zoster complicated with malignant tumors

目的分析带状疱疹(HZ)合并恶性肿瘤患者的临床特征及影响因素。方法68例HZ患者分为两组:观察组33例,合并恶性肿瘤;对照组35例,未合并恶性肿瘤。收集两组患者的临床资料及实验室检查指标,分析HZ合并恶性肿瘤的危险因素。结果观察组HZ发病年龄、D-二聚体、血清肌酐水平以及CD3^(+)T淋巴细胞降低、CD8^(+)T淋巴细胞降低占比高于对照组(P<0.05)。观察组中,HZ发病时间晚于恶性肿瘤者28例(84.85%),HZ发病时间早于恶性肿瘤者5例(15.15%),两病间隔时间在6个月以内者9例(27.27%)。观察组患者合并8种恶性肿瘤;其中,合并血液系统肿瘤的比例最高(33.33%)。CD3^(+)T淋巴细胞降低是HZ合并恶性肿瘤的独立危险因素(P<0.05)。结论HZ合并恶性肿瘤患者HZ发病年龄较高,合并血液系统肿瘤的比例较高,CD3^(+)T淋巴细胞降低是HZ合并恶性肿瘤的独立危险因素。

Objective To analyze the clinical characteristics and influencing factors in the patients with herpes zoster(HZ)complicated with malignant tumors.Methods A total of 68 HZ patients were divided into two groups.The patients in group A(33 cases)were complicated with malignant tumors and those in group B(35 cases)were not complicated with malignant tumors.The clinical data and laboratory test indexes were collected and the risk factors for HZ patients to complicate malignant tumors were analyzed.Results Compared to group B,group A was older in onset age and had higher D-dimer,serum creatinine and proportions of decreased CD3^(+)T lymphocytes and CD8^(+)T lymphocytes(P<0.05).In group A,the onset time of HZ was later than that of malignant tumors in 28 cases(84.85%),the onset time was earlier than that of malignant tumors in 5 cases(15.15%),and the interval between the two diseases was less than 6 months in 9 cases(27.27%).The patients in group A were complicated with 8 kinds of malignant tumors,among which the proportion of hematological tumors was the highest(33.33%).The decrease of CD3^(+)T lymphocytes was the independent risk factor for HZ patients complicated with malignant tumors(P<0.05).Conclusion The HZ patients complicated with malignant tumors have older onset age and higher proportion of hematological tumors.The decrease of CD3^(+)T lymphocytes is an independent risk factor for HZ patients to complicate malignant tumors.