血液指标在自发性脑出血中的临床意义

Clinical significance of blood indicators in spontaneous intracerebral hemorrhage

目的探讨血液指标在自发性脑出血(sICH)中的临床意义。方法检测117例sICH患者血液指标,计算中性粒细胞与淋巴细胞比值(NLR)和血小板与淋巴细胞比值(PLR)。采用美国国立卫生研究院卒中量表(NIHSS)评估患者神经功能缺损程度,根据NIHSS评分将患者分为A组(NIHSS评分≤5分,60例)和B组(NIHSS评分>5分,57例)。采用Spearman相关性分析血液指标与NIHSS评分的关系,多重线性回归分析NIHSS评分的影响因素。结果A组TC和LDL-C高于B组,而超敏C反应蛋白和NLR低于B组(P<0.05)。TC、LDL-C与NIHSS评分呈负相关(r_(s)=-0.24、-0.26,P<0.05),D-二聚体、NLR和WBC与NIHSS评分呈正相关(r_(s)=0.19、0.20和0.19,P<0.05)。多重线性回归分析发现,D-二聚体、NLR和空腹血糖是sICH患者NIHSS评分的影响因素(P<0.05)。结论血液指标与sICH患者神经功能缺损程度有关,D-二聚体、NLR和空腹血糖是其影响因素。

Objective To explore the clinical significance of blood indicators in spontaneous intracerebral hemorrhage(sICH).Methods The blood indicators were detected in 117 patients with sICH.The neutrophil to lymphocyte ratio(NLR)and platelet to lymphocyte ratio(PLR)were calculated.The degree of neurological impairment was assessed by National Institutes of Health Stroke Scale(NIHSS).The patients were divided into two groups of A(NIHSS score≤5 points,60 cases)and B(NIHSS score>5 points,57 cases).The influencing factors for NIHSS score were analyzed by multiple linear regression analysis.Results The TC and LDL-C in group A were higher than those in group B,while hypersensitive C-reactive protein and NLR were lower than those in group B(P<0.05).TC and LDL-C were negatively correlated with NIHSS score(r_(s)=-0.24 and-0.26,P<0.05),and D-dimer,NLR and WBC were positively correlated with NIHSS score(r_(s)=0.19,0.20 and 0.19,P<0.05).Multiple linear regression analysis showed that D-dimer,NLR and fasting blood glucose were the influencing factors for NIHSS score in sICH patients(P<0.05).Conclusion Blood indicators are related to the degree of neurological impairment in sICH patients,and D-dimer,NLR and fasting blood glucose are the influencing factors.