早期神经介入栓塞术在老年颅内动脉瘤破裂患者治疗中的应用效果分析

Analysis of application effect of early neurointerventional embolization in the treatment of elderly patients with ruptured intracranial aneurysms

目的 探讨老年颅内动脉瘤破裂患者给予早期神经介入栓塞术治疗的效果。方法 选取28例老年颅内动脉瘤破裂患者,随机分为观察组(采用早期神经介入栓塞术治疗)和对照组(采用晚期神经介入栓塞术治疗),各14例。比较两组患者的并发症发生情况,血管内皮功能指标[一氧化氮(NO)、血管性血友病因子(vWF)、内皮素-1(ET-1)]水平。结果 两组患者的脑水肿、下肢静脉血栓、再破裂出血、肺部感染发生率比较,差异无统计学意义(P>0.05)。术前,观察组NO为(53.15±8.05)μmol/L、vWF为(117.85±25.42)ng/ml、ET-1为(78.55±6.47)pg/ml,对照组NO为(53.95±8.51)μmol/L、vWF为(118.25±26.12)ng/ml、ET-1为(79.22±6.74)pg/ml,比较差异无统计学意义(P>0.05);术后,观察组NO为(72.15±10.25)μmol/L、vWF为(69.45±7.23)ng/ml、ET-1为(43.41±7.20)pg/ml,对照组NO为(88.15±9.66)μmol/L、vWF为(94.33±8.01)ng/ml、ET-1为(56.23±6.81)pg/ml,观察组均低于对照组,差异具有统计学意义(P<0.05)。结论 早期神经介入栓塞术在老年颅内动脉瘤破裂中的治疗效果良好,价值较高。

Objective To explore the effect of early neurointerventional embolization in the treatment of elderly patients with ruptured intracranial aneurysms.Methods 28 elderly patients with ruptured intracranial aneurysms were randomly divided into an observation group(early neurointerventional embolization)and a control group(late neurointerventional embolization),with 14 patients in each group.The occurrence of complications and the levels of vascular endothelial function indicators[nitric oxide(NO),von Willebrands factor(vWF)and endothelin-1(ET-1)]were compared between the two groups.Results There was no significant difference in the incidence of cerebral edema,lower limb venous thrombosis,re-rupture hemorrhage and pulmonary infection between the two groups(P>0.05).Before surgery,NO,vWF and ET-1 in the observation group were(53.15±8.05)μmol/L,(117.85±25.42)ng/ml and(78.55±6.47)pg/ml,and those in the control group were(53.95±8.51)μmol/L,(118.25±26.12)ng/ml and(79.22±6.74)pg/ml.There was no significant difference between the two groups(P>0.05).After surgery,NO,vWF and ET-1 in the observation group were(72.15±10.25)μmol/L,(69.45±7.23)ng/ml and(43.41±7.20)pg/ml,and those in the control group were(88.15±9.66)μmol/L,(94.33±8.01)ng/ml and(56.23±6.81)pg/ml;the observation group was lower than the control group,and the difference was statistically significant(P<0.05).Conclusion Early neurointerventional embolization is effective and valuable in the treatment of ruptured intracranial aneurysms in the elderly.